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A majority of the malignant cells showed moderate to strong cytoplasmic and membranous staining. Many skin, testicular and breast cancers were weakly stained or negative. Gliomas and lymphomas were mainly negative.
Majority of cancer tissue showed moderate to strong membranous positivity with additional cytoplasmic staining in several cases. Lymphomas, gliomas along with several cases of breast, testis, urothelial and renal cancers were negative.
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]