Cell atlas - EIF4E3 - The Human Protein Atlas

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EIF4E3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli fibrillar center

Human cell
	Nucleoli

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GENERAL INFORMATION
Gene name	EIF4E3
Gene description	Eukaryotic translation initiation factor 4E family member 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli (fibrillar center).
RNA cell category	Cell line enhanced (U-937)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli fibrillar center (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA058649
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-937) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli (fibrillar center).

Main location

Nucleoli fibrillar center (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA058649	SH-SY5Y	Nucleoli fibrillar center
	HPA058649	SiHa	No staining
	HPA058649	U-2 OS	No staining

GENE INFORMATION
Gene name	EIF4E3 (HGNC Symbol)
Synonyms	MGC39820
Description	Eukaryotic translation initiation factor 4E family member 3 (HGNC Symbol)
Entrez gene summary	EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al., 2004 [PubMed 15153109]).[supplied by OMIM, Mar 2008]
Chromosome	3
Cytoband	p13
Chromosome location (bp)	71675416 - 71754773
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163412 (version 83.38)
Entrez gene	317649
UniProt	Q8N5X7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N5X7
Antibodypedia	EIF4E3 antibodies

PROTEIN BROWSER

EIF4E3-001	EIF4E3-002	EIF4E3-004	EIF4E3-005	EIF4E3-007	EIF4E3-008	EIF4E3-201	EIF4E3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EIF4E3-001 ENSP00000393324 ENST00000425534	Q8N5X7 [Direct mapping] Eukaryotic translation initiation factor 4E type 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003723 [RNA binding] GO:0003743 [translation initiation factor activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005845 [mRNA cap binding complex] GO:0006413 [translational initiation] GO:0006417 [regulation of translation] GO:0019221 [cytokine-mediated signaling pathway] Show all	224 aa 24.4 kDa	No	0
EIF4E3-002 ENSP00000295612 ENST00000295612	Q8N5X7 [Direct mapping] Eukaryotic translation initiation factor 4E type 3 Show all	Predicted intracellular proteins Show all	GO:0003723 [RNA binding] GO:0003743 [translation initiation factor activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005845 [mRNA cap binding complex] GO:0006413 [translational initiation] GO:0006417 [regulation of translation] GO:0019221 [cytokine-mediated signaling pathway] Show all	118 aa 13.3 kDa	No	0
EIF4E3-004 ENSP00000411762 ENST00000421769	Q8N5X7 [Direct mapping] Eukaryotic translation initiation factor 4E type 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003723 [RNA binding] GO:0003743 [translation initiation factor activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005845 [mRNA cap binding complex] GO:0006413 [translational initiation] GO:0006417 [regulation of translation] GO:0019221 [cytokine-mediated signaling pathway] Show all	118 aa 13.3 kDa	No	0
EIF4E3-005 ENSP00000417889 ENST00000496214	C9J6E5 [Direct mapping] Eukaryotic translation initiation factor 4E type 3 Show all	Predicted intracellular proteins Show all	GO:0003723 [RNA binding] GO:0003743 [translation initiation factor activity] GO:0005737 [cytoplasm] GO:0006413 [translational initiation] Show all	51 aa 5.8 kDa	No	0
EIF4E3-007 ENSP00000418211 ENST00000497838	C9J7Z6 [Direct mapping] Eukaryotic translation initiation factor 4E type 3 Show all	Predicted intracellular proteins Show all	GO:0003723 [RNA binding] GO:0003743 [translation initiation factor activity] GO:0005737 [cytoplasm] GO:0006413 [translational initiation] Show all	93 aa 10.4 kDa	No	0
EIF4E3-008 ENSP00000419421 ENST00000469524	C9JUY2 [Direct mapping] Eukaryotic translation initiation factor 4E type 3 Show all	Predicted intracellular proteins Show all	GO:0003723 [RNA binding] GO:0003743 [translation initiation factor activity] GO:0005737 [cytoplasm] GO:0006413 [translational initiation] Show all	44 aa 5.1 kDa	No	0
EIF4E3-201 ENSP00000374476 ENST00000389826	Q8N5X7 [Direct mapping] Eukaryotic translation initiation factor 4E type 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003723 [RNA binding] GO:0003743 [translation initiation factor activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005845 [mRNA cap binding complex] GO:0006413 [translational initiation] GO:0006417 [regulation of translation] GO:0019221 [cytokine-mediated signaling pathway] Show all	118 aa 13.3 kDa	No	0
EIF4E3-202 ENSP00000410350 ENST00000448225	Q8N5X7 [Direct mapping] Eukaryotic translation initiation factor 4E type 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003723 [RNA binding] GO:0003743 [translation initiation factor activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005845 [mRNA cap binding complex] GO:0006413 [translational initiation] GO:0006417 [regulation of translation] GO:0019221 [cytokine-mediated signaling pathway] Show all	118 aa 13.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.