Expression of PDCL2 in cancer - Summary - The Human Protein Atlas

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PDCL2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PDCL2
Gene description	Phosducin-like 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (endometrial cancer, ovarian cancer, testis cancer)
HPA (cell line):	Cell line enhanced (HaCaT)
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in seminiferous ducts of testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 1 antibody. HPA048260
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (endometrial cancer, ovarian cancer, testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048260

GENE INFORMATION
Gene name	PDCL2 (HGNC Symbol)
Synonyms	GCPHLP
Description	Phosducin-like 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q12
Chromosome location (bp)	55556525 - 55592212
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163440 (version 83.38)
Entrez gene	132954
UniProt	Q8N4E4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N4E4
Antibodypedia	PDCL2 antibodies

PROTEIN BROWSER

PDCL2-001	PDCL2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDCL2-001 ENSP00000295645 ENST00000295645	Q8N4E4 [Direct mapping] Phosducin-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all		241 aa 28.1 kDa	No	0
PDCL2-201 ENSP00000480111 ENST00000615028	A0A087WWC3 [Direct mapping] Phosducin-like protein 2 Show all	Predicted intracellular proteins Show all		250 aa 29.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.