Expression of IGFBP7 in cancer - Summary

GENERAL INFORMATION
Gene name	IGFBP7
Gene description	Insulin-like growth factor binding protein 7
Protein class	Disease related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (BJ, BJ hTERT+, EFO-21, RPTEC TERT1, TIME)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Plasma positivity in several tissues. Cytoplasmic expression mainly in pancreatic islet cells, renal tubules and Leydig cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 2 antibodies. HPA002196 , CAB020668
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA002196	CAB020668

GENE INFORMATION
Gene name	IGFBP7 (HGNC Symbol)
Synonyms	FSTL2, IGFBP-7, MAC25, PSF
Description	Insulin-like growth factor binding protein 7 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]
Chromosome	4
Cytoband	q12
Chromosome location (bp)	57030773 - 57110385
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163453 (version 83.38)
Entrez gene	3490
UniProt	Q16270 (UniProt - Evidence at protein level)
neXtProt	NX_Q16270
Antibodypedia	IGFBP7 antibodies

PROTEIN BROWSER

IGFBP7-001	IGFBP7-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IGFBP7-001 ENSP00000295666 ENST00000295666	Q16270 [Direct mapping] Insulin-like growth factor-binding protein 7 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005515 [protein binding] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007155 [cell adhesion] GO:0008285 [negative regulation of cell proliferation] GO:0031012 [extracellular matrix] GO:0048839 [inner ear development] GO:0070062 [extracellular exosome] Show all	282 aa 29.1 kDa	Yes	0
IGFBP7-003 ENSP00000486293 ENST00000514062	Q16270 [Direct mapping] Insulin-like growth factor-binding protein 7 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005515 [protein binding] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007155 [cell adhesion] GO:0008285 [negative regulation of cell proliferation] GO:0031012 [extracellular matrix] GO:0070062 [extracellular exosome] Show all	279 aa 28.9 kDa	Yes	0