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CXCR1

GENERAL INFORMATION

Gene name

 CXCR1

Gene description

 Chemokine (C-X-C motif) receptor 1

Protein class

 Cancer-related genes
CD markers
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (HMC-1)
HPA (normal tissue):Tissue enhanced (appendix, spleen)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, including immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA031991
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA031991

GENE INFORMATION

Gene name

 CXCR1 (HGNC Symbol)

Synonyms

 CD181, CDw128a, CKR-1, CMKAR1, IL8RA

Description

 Chemokine (C-X-C motif) receptor 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q35

Chromosome location (bp)

 218162845 - 218166995

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163464 (version 83.38)

Entrez gene

 3577

UniProt

 P25024 (UniProt - Evidence at protein level)

neXtProt

 NX_P25024

Antibodypedia

 CXCR1 antibodies

PROTEIN BROWSER
CXCR1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CXCR1-001
ENSP00000295683
ENST00000295683
P25024 [Direct mapping]
C-X-C chemokine receptor type 1
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CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
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GO:0002407 [dendritic cell chemotaxis]
GO:0004918 [interleukin-8 receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005886 [plasma membrane]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019959 [interleukin-8 binding]
GO:0031623 [receptor internalization]
GO:0038112 [interleukin-8-mediated signaling pathway]
GO:0070098 [chemokine-mediated signaling pathway]
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 350 aa
39.8 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.