We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
NEK10
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

NEK10

Gene description

NIMA-related kinase 10

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (breast cancer)
HPA (cell line):Cell line enhanced (LHCN-M2, U-2 OS)
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA038941
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in breast cancer (favourable).
Breast cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (breast cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA038941

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

The majority of malignant cells were negative. Luminal membranous positivity was observed i a few cases of colorectal cancers. Nuclear immunoreactivity was observed in a few cases of testicular, pancreatic and ovarian cancers.

GENE INFORMATION

Gene name

NEK10 (HGNC Symbol)

Synonyms

FLJ32685

Description

NIMA-related kinase 10 (HGNC Symbol)

Entrez gene summary

Chromosome

3

Cytoband

p24.1

Chromosome location (bp)

27110085 - 27369460

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163491 (version 83.38)

Entrez gene

152110

UniProt

Q6ZWH5 (UniProt - Evidence at transcript level)

neXtProt

NX_Q6ZWH5

Antibodypedia

NEK10 antibodies

PROTEIN BROWSER

NEK10-001
NEK10-003
NEK10-005
NEK10-008
NEK10-009
NEK10-015
NEK10-016
NEK10-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NEK10-001
ENSP00000373281
ENST00000383771
Q6ZWH5 [Direct mapping]
Serine/threonine-protein kinase Nek10
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0046872 [metal ion binding]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:1902749 [regulation of cell cycle G2/M phase transition]
GO:1902911 [protein kinase complex]
Show all
474 aa
53.1 kDa
No 0
NEK10-003
ENSP00000343847
ENST00000341435
Q6ZWH5 [Direct mapping]
Serine/threonine-protein kinase Nek10
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005488 [binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0046872 [metal ion binding]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:1902749 [regulation of cell cycle G2/M phase transition]
GO:1902911 [protein kinase complex]
Show all
712 aa
81.6 kDa
No 0
NEK10-005
ENSP00000395338
ENST00000435750
C9JJN0 [Direct mapping]
Serine/threonine-protein kinase Nek10
Show all
Predicted intracellular proteins
Show all
133 aa
15.6 kDa
No 0
NEK10-008
ENSP00000392344
ENST00000424275
H7C000 [Direct mapping]
Serine/threonine-protein kinase Nek10
Show all
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
196 aa
22.6 kDa
No 0
NEK10-009
ENSP00000412651
ENST00000435584
H7C3L8 [Direct mapping]
Serine/threonine-protein kinase Nek10
Show all
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
166 aa
19.3 kDa
No 0
NEK10-015
ENSP00000295720
ENST00000295720
Q6ZWH5 [Direct mapping]
Serine/threonine-protein kinase Nek10
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0046872 [metal ion binding]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:1902749 [regulation of cell cycle G2/M phase transition]
GO:1902911 [protein kinase complex]
Show all
484 aa
54.2 kDa
No 0
NEK10-016
ENSP00000395849
ENST00000429845
Q6ZWH5 [Direct mapping]
Serine/threonine-protein kinase Nek10
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005488 [binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0046872 [metal ion binding]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:1902749 [regulation of cell cycle G2/M phase transition]
GO:1902911 [protein kinase complex]
Show all
1172 aa
133.3 kDa
No 0
NEK10-201
ENSP00000373280
ENST00000383770
A0A0A0MRY8 [Direct mapping]
Serine/threonine-protein kinase Nek10
Show all
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
418 aa
46.8 kDa
No 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.