Expression of NEK10 in cancer - Summary - The Human Protein Atlas

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NEK10

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NEK10
Gene description	NIMA-related kinase 10
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (breast cancer)
HPA (cell line):	Cell line enhanced (LHCN-M2, U-2 OS)
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA038941
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable).
Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (breast cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038941

GENE INFORMATION
Gene name	NEK10 (HGNC Symbol)
Synonyms	FLJ32685
Description	NIMA-related kinase 10 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p24.1
Chromosome location (bp)	27110085 - 27369460
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163491 (version 83.38)
Entrez gene	152110
UniProt	Q6ZWH5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6ZWH5
Antibodypedia	NEK10 antibodies

PROTEIN BROWSER

NEK10-001	NEK10-003	NEK10-005	NEK10-008	NEK10-009	NEK10-015	NEK10-016	NEK10-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NEK10-001 ENSP00000373281 ENST00000383771	Q6ZWH5 [Direct mapping] Serine/threonine-protein kinase Nek10 Show all	Enzymes ENZYME proteins Transferases Kinases NEK Ser/Thr protein kinases Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0031954 [positive regulation of protein autophosphorylation] GO:0043406 [positive regulation of MAP kinase activity] GO:0046872 [metal ion binding] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:1902749 [regulation of cell cycle G2/M phase transition] GO:1902911 [protein kinase complex] Show all	474 aa 53.1 kDa	No	0
NEK10-003 ENSP00000343847 ENST00000341435	Q6ZWH5 [Direct mapping] Serine/threonine-protein kinase Nek10 Show all	Enzymes ENZYME proteins Transferases Kinases NEK Ser/Thr protein kinases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005488 [binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0031954 [positive regulation of protein autophosphorylation] GO:0043406 [positive regulation of MAP kinase activity] GO:0046872 [metal ion binding] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:1902749 [regulation of cell cycle G2/M phase transition] GO:1902911 [protein kinase complex] Show all	712 aa 81.6 kDa	No	0
NEK10-005 ENSP00000395338 ENST00000435750	C9JJN0 [Direct mapping] Serine/threonine-protein kinase Nek10 Show all	Predicted intracellular proteins Show all		133 aa 15.6 kDa	No	0
NEK10-008 ENSP00000392344 ENST00000424275	H7C000 [Direct mapping] Serine/threonine-protein kinase Nek10 Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	196 aa 22.6 kDa	No	0
NEK10-009 ENSP00000412651 ENST00000435584	H7C3L8 [Direct mapping] Serine/threonine-protein kinase Nek10 Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	166 aa 19.3 kDa	No	0
NEK10-015 ENSP00000295720 ENST00000295720	Q6ZWH5 [Direct mapping] Serine/threonine-protein kinase Nek10 Show all	Enzymes ENZYME proteins Transferases Kinases NEK Ser/Thr protein kinases Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0031954 [positive regulation of protein autophosphorylation] GO:0043406 [positive regulation of MAP kinase activity] GO:0046872 [metal ion binding] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:1902749 [regulation of cell cycle G2/M phase transition] GO:1902911 [protein kinase complex] Show all	484 aa 54.2 kDa	No	0
NEK10-016 ENSP00000395849 ENST00000429845	Q6ZWH5 [Direct mapping] Serine/threonine-protein kinase Nek10 Show all	Enzymes ENZYME proteins Transferases Kinases NEK Ser/Thr protein kinases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005488 [binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0031954 [positive regulation of protein autophosphorylation] GO:0043406 [positive regulation of MAP kinase activity] GO:0046872 [metal ion binding] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:1902749 [regulation of cell cycle G2/M phase transition] GO:1902911 [protein kinase complex] Show all	1172 aa 133.3 kDa	No	0
NEK10-201 ENSP00000373280 ENST00000383770	A0A0A0MRY8 [Direct mapping] Serine/threonine-protein kinase Nek10 Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	418 aa 46.8 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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