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FEV

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GENERAL INFORMATION

Gene name

 FEV

Gene description

 FEV (ETS oncogene family)

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nuclear speckles.

RNA cell category

 Group enriched (SH-SY5Y, HMC-1)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear speckles (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA067679
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (SH-SY5Y, HMC-1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nuclear speckles.

Main location

 Nuclear speckles (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA067679 SH-SY5Y Nuclear speckles
HPA067679 U-2 OS Nuclear speckles

GENE INFORMATION

Gene name

 FEV (HGNC Symbol)

Synonyms

 Pet-1

Description

 FEV (ETS oncogene family) (HGNC Symbol)

Entrez gene summary

 This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q35

Chromosome location (bp)

 218981087 - 218985657

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163497 (version 83.38)

Entrez gene

 54738

UniProt

 Q99581 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99581

Antibodypedia

 FEV antibodies

PROTEIN BROWSER
FEV-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FEV-001
ENSP00000295727
ENST00000295727
Q99581 [Direct mapping]
Protein FEV
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
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GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0010628 [positive regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0042551 [neuron maturation]
GO:0043565 [sequence-specific DNA binding]
GO:0048665 [neuron fate specification]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
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 238 aa
25 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.