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TGFBR2
  • TISSUE

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  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Dictionary

GENERAL INFORMATION

Gene name

TGFBR2

Gene description

Transforming growth factor, beta receptor II (70/80kDa)

Protein class

Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (ASC TERT1, EFO-21, LHCN-M2, TIME)
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

Pending cancer tissue analysis.

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis


STAINING SUMMARY

 

GENE INFORMATION

Gene name

TGFBR2 (HGNC Symbol)

Synonyms

MFS2

Description

Transforming growth factor, beta receptor II (70/80kDa) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

p24.1

Chromosome location (bp)

30606502 - 30694142

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163513 (version 83.38)

Entrez gene

7048

UniProt

P37173 (UniProt - Evidence at protein level)

neXtProt

NX_P37173

Antibodypedia

TGFBR2 antibodies

PROTEIN BROWSER

TGFBR2-001
TGFBR2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TGFBR2-001
ENSP00000295754
ENST00000295754
P37173 [Direct mapping]
TGF-beta receptor type-2
A3QNQ0 [Target identity:100%; Query identity:100%]
TGF-beta receptor type-2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001568 [blood vessel development]
GO:0001569 [patterning of blood vessels]
GO:0001570 [vasculogenesis]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0002651 [positive regulation of tolerance induction to self antigen]
GO:0002663 [positive regulation of B cell tolerance induction]
GO:0002666 [positive regulation of T cell tolerance induction]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0004872 [receptor activity]
GO:0005024 [transforming growth factor beta-activated receptor activity]
GO:0005026 [transforming growth factor beta receptor activity, type II]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005539 [glycosaminoglycan binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007420 [brain development]
GO:0007507 [heart development]
GO:0008284 [positive regulation of cell proliferation]
GO:0009897 [external side of plasma membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0032147 [activation of protein kinase activity]
GO:0034713 [type I transforming growth factor beta receptor binding]
GO:0034714 [type III transforming growth factor beta receptor binding]
GO:0035162 [embryonic hemopoiesis]
GO:0040008 [regulation of growth]
GO:0042127 [regulation of cell proliferation]
GO:0042493 [response to drug]
GO:0043011 [myeloid dendritic cell differentiation]
GO:0043235 [receptor complex]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0050431 [transforming growth factor beta binding]
GO:0051138 [positive regulation of NK T cell differentiation]
GO:0060021 [palate development]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0070022 [transforming growth factor beta receptor homodimeric complex]
GO:0070723 [response to cholesterol]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
567 aa
64.6 kDa
Yes 1
TGFBR2-002
ENSP00000351905
ENST00000359013
P37173 [Direct mapping]
TGF-beta receptor type-2
D2JYI1 [Target identity:100%; Query identity:100%]
TGF-beta receptor type-2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001568 [blood vessel development]
GO:0001569 [patterning of blood vessels]
GO:0001570 [vasculogenesis]
GO:0001701 [in utero embryonic development]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0002088 [lens development in camera-type eye]
GO:0002651 [positive regulation of tolerance induction to self antigen]
GO:0002663 [positive regulation of B cell tolerance induction]
GO:0002666 [positive regulation of T cell tolerance induction]
GO:0003417 [growth plate cartilage development]
GO:0003430 [growth plate cartilage chondrocyte growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0004872 [receptor activity]
GO:0005024 [transforming growth factor beta-activated receptor activity]
GO:0005026 [transforming growth factor beta receptor activity, type II]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005539 [glycosaminoglycan binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005901 [caveola]
GO:0006468 [protein phosphorylation]
GO:0006898 [receptor-mediated endocytosis]
GO:0006915 [apoptotic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007182 [common-partner SMAD protein phosphorylation]
GO:0007219 [Notch signaling pathway]
GO:0007224 [smoothened signaling pathway]
GO:0007369 [gastrulation]
GO:0007420 [brain development]
GO:0007507 [heart development]
GO:0007566 [embryo implantation]
GO:0007568 [aging]
GO:0007584 [response to nutrient]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0009612 [response to mechanical stimulus]
GO:0009749 [response to glucose]
GO:0009887 [organ morphogenesis]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010033 [response to organic substance]
GO:0010468 [regulation of gene expression]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030324 [lung development]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0031100 [organ regeneration]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0032147 [activation of protein kinase activity]
GO:0034713 [type I transforming growth factor beta receptor binding]
GO:0034714 [type III transforming growth factor beta receptor binding]
GO:0035162 [embryonic hemopoiesis]
GO:0040008 [regulation of growth]
GO:0042060 [wound healing]
GO:0042127 [regulation of cell proliferation]
GO:0042493 [response to drug]
GO:0043011 [myeloid dendritic cell differentiation]
GO:0043235 [receptor complex]
GO:0043415 [positive regulation of skeletal muscle tissue regeneration]
GO:0043627 [response to estrogen]
GO:0045121 [membrane raft]
GO:0045766 [positive regulation of angiogenesis]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0048545 [response to steroid hormone]
GO:0048565 [digestive tract development]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0050431 [transforming growth factor beta binding]
GO:0051138 [positive regulation of NK T cell differentiation]
GO:0051216 [cartilage development]
GO:0060021 [palate development]
GO:0060044 [negative regulation of cardiac muscle cell proliferation]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0060425 [lung morphogenesis]
GO:0060433 [bronchus development]
GO:0060434 [bronchus morphogenesis]
GO:0060439 [trachea morphogenesis]
GO:0060440 [trachea formation]
GO:0060443 [mammary gland morphogenesis]
GO:0060463 [lung lobe morphogenesis]
GO:0070022 [transforming growth factor beta receptor homodimeric complex]
GO:0070723 [response to cholesterol]
GO:1990086 [lens fiber cell apoptotic process]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
592 aa
67.5 kDa
No 1

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The Human Protein Atlas project is funded
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