Expression of ANKZF1 in cancer - Summary - The Human Protein Atlas

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ANKZF1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ANKZF1
Gene description	Ankyrin repeat and zinc finger domain containing 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA035208
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035208

GENE INFORMATION
Gene name	ANKZF1 (HGNC Symbol)
Synonyms	FLJ10415, ZNF744
Description	Ankyrin repeat and zinc finger domain containing 1 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q35
Chromosome location (bp)	219229757 - 219236669
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163516 (version 83.38)
Entrez gene	55139
UniProt	Q9H8Y5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H8Y5
Antibodypedia	ANKZF1 antibodies

PROTEIN BROWSER

ANKZF1-001	ANKZF1-003	ANKZF1-008	ANKZF1-011	ANKZF1-017	ANKZF1-018	ANKZF1-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANKZF1-001 ENSP00000321617 ENST00000323348	Q9H8Y5 [Direct mapping] Ankyrin repeat and zinc finger domain-containing protein 1 A0A024R464 [Target identity:100%; Query identity:100%] Ankyrin repeat and zinc finger domain containing 1, isoform CRA_b Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0016020 [membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0036266 [Cdc48p-Npl4p-Vms1p AAA ATPase complex] GO:0046872 [metal ion binding] GO:0071630 [nucleus-associated proteasomal ubiquitin-dependent protein catabolic process] GO:0072671 [mitochondria-associated ubiquitin-dependent protein catabolic process] Show all	726 aa 80.9 kDa	No	0
ANKZF1-003 ENSP00000386815 ENST00000409849	B8ZZS4 [Direct mapping] Ankyrin repeat and zinc finger domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	516 aa 57.6 kDa	No	0
ANKZF1-008 ENSP00000386337 ENST00000410034	Q9H8Y5 [Direct mapping] Ankyrin repeat and zinc finger domain-containing protein 1 A0A024R464 [Target identity:100%; Query identity:100%] Ankyrin repeat and zinc finger domain containing 1, isoform CRA_b Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0016020 [membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0036266 [Cdc48p-Npl4p-Vms1p AAA ATPase complex] GO:0046872 [metal ion binding] GO:0071630 [nucleus-associated proteasomal ubiquitin-dependent protein catabolic process] GO:0072671 [mitochondria-associated ubiquitin-dependent protein catabolic process] Show all	726 aa 80.9 kDa	No	0
ANKZF1-011 ENSP00000394359 ENST00000453432	C9JS61 [Direct mapping] Ankyrin repeat and zinc finger domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046872 [metal ion binding] Show all	115 aa 13.5 kDa	No	0
ANKZF1-017 ENSP00000406514 ENST00000416565	C9J5H7 [Direct mapping] Ankyrin repeat and zinc finger domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		60 aa 6.6 kDa	No	0
ANKZF1-018 ENSP00000399667 ENST00000447157	C9K022 [Direct mapping] Ankyrin repeat and zinc finger domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046872 [metal ion binding] Show all	140 aa 15.3 kDa	No	0
ANKZF1-019 ENSP00000394652 ENST00000436226	C9JQZ3 [Direct mapping] Ankyrin repeat and zinc finger domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		90 aa 9.6 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.