Expression of FCRL4 in cancer - Summary - The Human Protein Atlas

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FCRL4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FCRL4
Gene description	Fc receptor-like 4
Protein class	Cancer-related genes CD markers Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enriched (U-266/70)
HPA (normal tissue):	Group enriched (appendix, lymph node, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in subsets of lymphoid cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA054030
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA054030

GENE INFORMATION
Gene name	FCRL4 (HGNC Symbol)
Synonyms	CD307d, FCRH4, IGFP2, IRTA1
Description	Fc receptor-like 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009]
Chromosome	1
Cytoband	q23.1
Chromosome location (bp)	157573749 - 157598080
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163518 (version 83.38)
Entrez gene	83417
UniProt	Q96PJ5 (UniProt - Evidence at protein level)
neXtProt	NX_Q96PJ5
Antibodypedia	FCRL4 antibodies

PROTEIN BROWSER

FCRL4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FCRL4-001 ENSP00000271532 ENST00000271532	Q96PJ5 [Direct mapping] Fc receptor-like protein 4 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Show all	GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	515 aa 57.2 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.