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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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TRAT1
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

TRAT1

Gene description

T cell receptor associated transmembrane adaptor 1

Protein class

Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (MOLT-4)
HPA (normal tissue):Tissue enhanced (appendix, lymph node)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in subsets of immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA002356 , CAB026130
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA002356
CAB026130

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

All cancers were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues were mainly negative.

GENE INFORMATION

Gene name

TRAT1 (HGNC Symbol)

Synonyms

HSPC062, TCRIM, TRIM

Description

T cell receptor associated transmembrane adaptor 1 (HGNC Symbol)

Entrez gene summary

Chromosome

3

Cytoband

q13.13

Chromosome location (bp)

108822698 - 108855005

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163519 (version 83.38)

Entrez gene

50852

UniProt

Q6PIZ9 (UniProt - Evidence at protein level)

neXtProt

NX_Q6PIZ9

Antibodypedia

TRAT1 antibodies

PROTEIN BROWSER

TRAT1-001
TRAT1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TRAT1-001
ENSP00000295756
ENST00000295756
Q6PIZ9 [Direct mapping]
T-cell receptor-associated transmembrane adapter 1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001920 [negative regulation of receptor recycling]
GO:0002250 [adaptive immune response]
GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006968 [cellular defense response]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042101 [T cell receptor complex]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0050852 [T cell receptor signaling pathway]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0051051 [negative regulation of transport]
Show all
186 aa
21.2 kDa
No 1
TRAT1-002
ENSP00000410097
ENST00000426646
C9JF66 [Direct mapping]
T-cell receptor-associated transmembrane adapter 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
149 aa
17.1 kDa
No 0

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