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STT3B

GENERAL INFORMATION

Gene name

 STT3B

Gene description

 STT3B, subunit of the oligosaccharyltransferase complex (catalytic)

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA036448 , HPA036646
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036448
HPA036646

GENE INFORMATION

Gene name

 STT3B (HGNC Symbol)

Synonyms

 FLJ90106, SIMP, STT3-B

Description

 STT3B, subunit of the oligosaccharyltransferase complex (catalytic) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a catalytic subunit of a protein complex that transfers oligosaccharides onto asparagine residues. Defects in this gene are a cause of congenital disorder of glycosylation Ix (CDG1X). [provided by RefSeq, Jun 2014]

Chromosome

 3

Cytoband

 p23

Chromosome location (bp)

 31532638 - 31637622

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163527 (version 83.38)

Entrez gene

 201595

UniProt

 Q8TCJ2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TCJ2

Antibodypedia

 STT3B antibodies

PROTEIN BROWSER
STT3B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STT3B-001
ENSP00000295770
ENST00000295770
Q8TCJ2 [Direct mapping]
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004576 [oligosaccharyl transferase activity]
GO:0004579 [dolichyl-diphosphooligosaccharide-protein glycotransferase activity]
GO:0005783 [endoplasmic reticulum]
GO:0006486 [protein glycosylation]
GO:0006516 [glycoprotein catabolic process]
GO:0006986 [response to unfolded protein]
GO:0008250 [oligosaccharyltransferase complex]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0043686 [co-translational protein modification]
GO:0043687 [post-translational protein modification]
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 826 aa
93.7 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.