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IFI16

GENERAL INFORMATION

Gene name

 IFI16

Gene description

 Interferon, gamma-inducible protein 16

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective nuclear expression, mainly in lymphoid tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA002134 , CAB016293
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA002134
CAB016293

GENE INFORMATION

Gene name

 IFI16 (HGNC Symbol)

Synonyms

 IFNGIP1, PYHIN2

Description

 Interferon, gamma-inducible protein 16 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]

Chromosome

 1

Cytoband

 q23.1

Chromosome location (bp)

 158999968 - 159055155

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163565 (version 83.38)

Entrez gene

 3428

UniProt

 Q16666 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16666

Antibodypedia

 IFI16 antibodies

PROTEIN BROWSER
«
IFI16-001
IFI16-002
IFI16-006
IFI16-007
IFI16-008
IFI16-009
IFI16-010
IFI16-011
IFI16-013
IFI16-014
IFI16-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IFI16-001
ENSP00000357113
ENST00000368131
Q16666 [Direct mapping]
Gamma-interferon-inducible protein 16
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001819 [positive regulation of cytokine production]
GO:0002218 [activation of innate immune response]
GO:0003690 [double-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006914 [autophagy]
GO:0006954 [inflammatory response]
GO:0008134 [transcription factor binding]
GO:0008283 [cell proliferation]
GO:0010506 [regulation of autophagy]
GO:0016020 [membrane]
GO:0016607 [nuclear speck]
GO:0030097 [hemopoiesis]
GO:0030099 [myeloid cell differentiation]
GO:0030224 [monocyte differentiation]
GO:0032481 [positive regulation of type I interferon production]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042149 [cellular response to glucose starvation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043392 [negative regulation of DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0045824 [negative regulation of innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051607 [defense response to virus]
GO:0071479 [cellular response to ionizing radiation]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0097202 [activation of cysteine-type endopeptidase activity]
GO:2000117 [negative regulation of cysteine-type endopeptidase activity]
Show all
 729 aa
82.1 kDa 		No 0
IFI16-002
ENSP00000357114
ENST00000368132
Q16666 [Direct mapping]
Gamma-interferon-inducible protein 16
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001819 [positive regulation of cytokine production]
GO:0002218 [activation of innate immune response]
GO:0003690 [double-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006914 [autophagy]
GO:0006954 [inflammatory response]
GO:0008134 [transcription factor binding]
GO:0008283 [cell proliferation]
GO:0010506 [regulation of autophagy]
GO:0016020 [membrane]
GO:0016607 [nuclear speck]
GO:0030097 [hemopoiesis]
GO:0030099 [myeloid cell differentiation]
GO:0030224 [monocyte differentiation]
GO:0032481 [positive regulation of type I interferon production]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042149 [cellular response to glucose starvation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043392 [negative regulation of DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0045824 [negative regulation of innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051607 [defense response to virus]
GO:0071479 [cellular response to ionizing radiation]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0097202 [activation of cysteine-type endopeptidase activity]
GO:2000117 [negative regulation of cysteine-type endopeptidase activity]
Show all
 729 aa
82.1 kDa 		No 0
IFI16-006
ENSP00000406406
ENST00000426592
H3BM18 [Direct mapping]
Gamma-interferon-inducible protein 16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 167 aa
18.3 kDa 		No 0
IFI16-007
ENSP00000407052
ENST00000447473
X6RHM1 [Direct mapping]
Gamma-interferon-inducible protein 16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 180 aa
19.6 kDa 		No 0
IFI16-008
ENSP00000456129
ENST00000474473
H3BR88 [Direct mapping]
Gamma-interferon-inducible protein 16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 229 aa
26 kDa 		No 0
IFI16-009
ENSP00000404325
ENST00000448393
Q16666 [Direct mapping]
Gamma-interferon-inducible protein 16
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001819 [positive regulation of cytokine production]
GO:0002218 [activation of innate immune response]
GO:0003690 [double-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006914 [autophagy]
GO:0006954 [inflammatory response]
GO:0008134 [transcription factor binding]
GO:0008283 [cell proliferation]
GO:0010506 [regulation of autophagy]
GO:0016020 [membrane]
GO:0016607 [nuclear speck]
GO:0030097 [hemopoiesis]
GO:0030099 [myeloid cell differentiation]
GO:0030224 [monocyte differentiation]
GO:0032481 [positive regulation of type I interferon production]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042149 [cellular response to glucose starvation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043392 [negative regulation of DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0045824 [negative regulation of innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051607 [defense response to virus]
GO:0071479 [cellular response to ionizing radiation]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0097202 [activation of cysteine-type endopeptidase activity]
GO:2000117 [negative regulation of cysteine-type endopeptidase activity]
Show all
 673 aa
75.9 kDa 		No 0
IFI16-010
ENSP00000458084
ENST00000566111
H3BVE6 [Direct mapping]
Gamma-interferon-inducible protein 16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 83 aa
9.7 kDa 		No 0
IFI16-011
ENSP00000456094
ENST00000567661
H3BR65 [Direct mapping]
Gamma-interferon-inducible protein 16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 74 aa
8.2 kDa 		No 0
IFI16-013
ENSP00000295809
ENST00000295809
Q16666 [Direct mapping]
Gamma-interferon-inducible protein 16
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001819 [positive regulation of cytokine production]
GO:0002218 [activation of innate immune response]
GO:0003690 [double-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006914 [autophagy]
GO:0006954 [inflammatory response]
GO:0008134 [transcription factor binding]
GO:0008283 [cell proliferation]
GO:0010506 [regulation of autophagy]
GO:0016020 [membrane]
GO:0016607 [nuclear speck]
GO:0030097 [hemopoiesis]
GO:0030099 [myeloid cell differentiation]
GO:0030224 [monocyte differentiation]
GO:0032481 [positive regulation of type I interferon production]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042149 [cellular response to glucose starvation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043392 [negative regulation of DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0045824 [negative regulation of innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051607 [defense response to virus]
GO:0071479 [cellular response to ionizing radiation]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0097202 [activation of cysteine-type endopeptidase activity]
GO:2000117 [negative regulation of cysteine-type endopeptidase activity]
Show all
 785 aa
88.3 kDa 		No 0
IFI16-014
ENSP00000352740
ENST00000359709
Q16666 [Direct mapping]
Gamma-interferon-inducible protein 16
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001819 [positive regulation of cytokine production]
GO:0002218 [activation of innate immune response]
GO:0003690 [double-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006914 [autophagy]
GO:0006954 [inflammatory response]
GO:0008134 [transcription factor binding]
GO:0008283 [cell proliferation]
GO:0010506 [regulation of autophagy]
GO:0016020 [membrane]
GO:0016607 [nuclear speck]
GO:0030097 [hemopoiesis]
GO:0030099 [myeloid cell differentiation]
GO:0030224 [monocyte differentiation]
GO:0032481 [positive regulation of type I interferon production]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042149 [cellular response to glucose starvation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043392 [negative regulation of DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0045824 [negative regulation of innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051607 [defense response to virus]
GO:0071479 [cellular response to ionizing radiation]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0097202 [activation of cysteine-type endopeptidase activity]
GO:2000117 [negative regulation of cysteine-type endopeptidase activity]
Show all
 729 aa
82.6 kDa 		No 0
IFI16-201
ENSP00000342741
ENST00000340979
A0A0A0MRB1 [Direct mapping]
Gamma-interferon-inducible protein 16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 243 aa
27.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.