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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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SLC2A2
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

SLC2A2

Gene description

Solute carrier family 2 (facilitated glucose transporter), member 2

Protein class

Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Group enriched (CACO-2, Hep G2)
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective membranous expression in hepatocytes, small intestine and renal tubules.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA028997 , CAB010444
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PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA028997
CAB010444

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cases of liver, renal and pancreatic cancers displayed moderate to strong membranous positivity. Remaining cancers tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate membranous positivity was observed in a fraction of hepatocellular carcinomas. Remaining cancers were weakly stained or negative.

GENE INFORMATION

Gene name

SLC2A2 (HGNC Symbol)

Synonyms

GLUT2

Description

Solute carrier family 2 (facilitated glucose transporter), member 2 (HGNC Symbol)

Entrez gene summary

This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Chromosome

3

Cytoband

q26.2

Chromosome location (bp)

170996348 - 171026750

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163581 (version 83.38)

Entrez gene

6514

UniProt

P11168 (UniProt - Evidence at protein level)

neXtProt

NX_P11168

Antibodypedia

SLC2A2 antibodies

PROTEIN BROWSER

SLC2A2-001
SLC2A2-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC2A2-001
ENSP00000323568
ENST00000314251
P11168 [Direct mapping]
Solute carrier family 2, facilitated glucose transporter member 2
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005158 [insulin receptor binding]
GO:0005215 [transporter activity]
GO:0005351 [sugar:proton symporter activity]
GO:0005355 [glucose transmembrane transporter activity]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005903 [brush border]
GO:0005911 [cell-cell junction]
GO:0005975 [carbohydrate metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0008645 [hexose transport]
GO:0009749 [response to glucose]
GO:0009758 [carbohydrate utilization]
GO:0015149 [hexose transmembrane transporter activity]
GO:0015755 [fructose transport]
GO:0015758 [glucose transport]
GO:0015992 [proton transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0022857 [transmembrane transporter activity]
GO:0022891 [substrate-specific transmembrane transporter activity]
GO:0031018 [endocrine pancreas development]
GO:0031526 [brush border membrane]
GO:0033300 [dehydroascorbic acid transporter activity]
GO:0035428 [hexose transmembrane transport]
GO:0043434 [response to peptide hormone]
GO:0044281 [small molecule metabolic process]
GO:0046323 [glucose import]
GO:0050796 [regulation of insulin secretion]
GO:0055056 [D-glucose transmembrane transporter activity]
GO:0055085 [transmembrane transport]
GO:0070837 [dehydroascorbic acid transport]
GO:1904659 [glucose transmembrane transport]
Show all
524 aa
57.5 kDa
No >9
SLC2A2-007
ENSP00000418888
ENST00000461867
C9J0E8 [Direct mapping]
Solute carrier family 2, facilitated glucose transporter member 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005351 [sugar:proton symporter activity]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0035428 [hexose transmembrane transport]
GO:0046323 [glucose import]
GO:0055085 [transmembrane transport]
Show all
103 aa
11.6 kDa
No 2

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