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FABP1

GENERAL INFORMATION

Gene name

 FABP1

Gene description

 Fatty acid binding protein 1, liver

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (colon, duodenum, liver, rectum, small intestine)
GTEx:Tissue enhanced (colon, liver, small intestine)
FANTOM5:Tissue enhanced (liver, small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression was observed in the liver, intestinal glands and renal tubules.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA028275 , CAB002305
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, duodenum, liver, rectum, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (colon, liver, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (liver, small intestine)

GENE INFORMATION

Gene name

 FABP1 (HGNC Symbol)

Synonyms

 L-FABP

Description

 Fatty acid binding protein 1, liver (HGNC Symbol)

Entrez gene summary

 This gene encodes the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. This protein and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Mar 2011]

Chromosome

 2

Cytoband

 p11.2

Chromosome location (bp)

 88122982 - 88128116

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163586 (version 83.38)

Entrez gene

 2168

UniProt

 P07148 (UniProt - Evidence at protein level)

neXtProt

 NX_P07148

Antibodypedia

 FABP1 antibodies

PROTEIN BROWSER
FABP1-001
FABP1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FABP1-001
ENSP00000295834
ENST00000295834
P07148 [Direct mapping]
Fatty acid-binding protein, liver
Q6FGL7 [Target identity:100%; Query identity:100%]
FABP1 protein; Fatty acid binding protein 1, liver, isoform CRA_b; Putative uncharacterized protein FABP1
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002230 [positive regulation of defense response to virus by host]
GO:0003682 [chromatin binding]
GO:0005215 [transporter activity]
GO:0005324 [long-chain fatty acid transporter activity]
GO:0005504 [fatty acid binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005782 [peroxisomal matrix]
GO:0005829 [cytosol]
GO:0006810 [transport]
GO:0008144 [drug binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008289 [lipid binding]
GO:0015909 [long-chain fatty acid transport]
GO:0016209 [antioxidant activity]
GO:0019433 [triglyceride catabolic process]
GO:0032000 [positive regulation of fatty acid beta-oxidation]
GO:0032052 [bile acid binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045179 [apical cortex]
GO:0050892 [intestinal absorption]
GO:0051345 [positive regulation of hydrolase activity]
GO:0070062 [extracellular exosome]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071456 [cellular response to hypoxia]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
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 127 aa
14.2 kDa 		No 0
FABP1-002
ENSP00000377351
ENST00000393750
A8MW49 [Direct mapping]
Fatty acid-binding protein, liver
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005215 [transporter activity]
GO:0006810 [transport]
GO:0008289 [lipid binding]
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 124 aa
13.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.