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CTLA4

GENERAL INFORMATION

Gene name

 CTLA4

Gene description

 Cytotoxic T-lymphocyte-associated protein 4

Protein class

 CD markers
Disease related genes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (SK-MEL-30, U-266/70, U-266/84)
HPA (normal tissue):Tissue enhanced (appendix, lymph node)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable).
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CTLA4 (HGNC Symbol)

Synonyms

 CD, CD152, CD28, CELIAC3, GSE, ICOS, IDDM12

Description

 Cytotoxic T-lymphocyte-associated protein 4 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q33.2

Chromosome location (bp)

 203867786 - 203873960

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163599 (version 83.38)

Entrez gene

 1493

UniProt

 P16410 (UniProt - Evidence at protein level)

neXtProt

 NX_P16410

Antibodypedia

 CTLA4 antibodies

PROTEIN BROWSER
CTLA4-001
CTLA4-002
CTLA4-004
CTLA4-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTLA4-001
ENSP00000303939
ENST00000302823
P16410 [Direct mapping]
Cytotoxic T-lymphocyte protein 4
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Show all
GO:0002250 [adaptive immune response]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0009897 [external side of plasma membrane]
GO:0030889 [negative regulation of B cell proliferation]
GO:0031295 [T cell costimulation]
GO:0043065 [positive regulation of apoptotic process]
GO:0045334 [clathrin-coated endocytic vesicle]
GO:0045590 [negative regulation of regulatory T cell differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050853 [B cell receptor signaling pathway]
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 223 aa
24.7 kDa 		Yes 1
CTLA4-002
ENSP00000409707
ENST00000427473
A0A0C4DH58 [Direct mapping]
Cytotoxic T-lymphocyte protein 4
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Predicted intracellular proteins
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GO:0005515 [protein binding]
GO:0006955 [immune response]
GO:0016020 [membrane]
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 137 aa
14.9 kDa 		No 0
CTLA4-004
ENSP00000417779
ENST00000472206
P16410 [Direct mapping]
Cytotoxic T-lymphocyte protein 4
Show all
CD markers
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
FDA approved drug targets
   Biotech drugs
Show all
GO:0002250 [adaptive immune response]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0009897 [external side of plasma membrane]
GO:0030889 [negative regulation of B cell proliferation]
GO:0031295 [T cell costimulation]
GO:0043065 [positive regulation of apoptotic process]
GO:0045334 [clathrin-coated endocytic vesicle]
GO:0045590 [negative regulation of regulatory T cell differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050853 [B cell receptor signaling pathway]
Show all
 79 aa
8.9 kDa 		Yes 0
CTLA4-005
ENSP00000295854
ENST00000295854
P16410 [Direct mapping]
Cytotoxic T-lymphocyte protein 4
Show all
CD markers
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
FDA approved drug targets
   Biotech drugs
Show all
GO:0002250 [adaptive immune response]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0009897 [external side of plasma membrane]
GO:0030889 [negative regulation of B cell proliferation]
GO:0031295 [T cell costimulation]
GO:0043065 [positive regulation of apoptotic process]
GO:0045334 [clathrin-coated endocytic vesicle]
GO:0045590 [negative regulation of regulatory T cell differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050853 [B cell receptor signaling pathway]
Show all
 174 aa
19.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.