Expression of CD200R1 in cancer - Summary - The Human Protein Atlas

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CD200R1

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	CD200R1
Gene description	CD200 receptor 1
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (HEL)
HPA (normal tissue):	Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	CD200R1 (HGNC Symbol)
Synonyms	CD200R, HCRTR2, MOX2R, OX2R
Description	CD200 receptor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q13.2
Chromosome location (bp)	112921209 - 112975122
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163606 (version 83.38)
Entrez gene	131450
UniProt	Q8TD46 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TD46
Antibodypedia	CD200R1 antibodies

PROTEIN BROWSER

CD200R1-001	CD200R1-002	CD200R1-003	CD200R1-004	CD200R1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD200R1-001 ENSP00000311035 ENST00000308611	Q8TD46 [Direct mapping] Cell surface glycoprotein CD200 receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0043235 [receptor complex] GO:0050776 [regulation of immune response] Show all	348 aa 39 kDa	Yes	1
CD200R1-002 ENSP00000418928 ENST00000471858	Q8TD46 [Direct mapping] Cell surface glycoprotein CD200 receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0043235 [receptor complex] GO:0050776 [regulation of immune response] Show all	325 aa 36.6 kDa	Yes	1
CD200R1-003 ENSP00000405733 ENST00000440122	Q8TD46 [Direct mapping] Cell surface glycoprotein CD200 receptor 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0043235 [receptor complex] GO:0050776 [regulation of immune response] Show all	188 aa 21.3 kDa	Yes	0
CD200R1-004 ENSP00000418801 ENST00000490004	Q8TD46 [Direct mapping] Cell surface glycoprotein CD200 receptor 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0043235 [receptor complex] GO:0050776 [regulation of immune response] Show all	165 aa 18.9 kDa	Yes	0
CD200R1-005 ENSP00000295863 ENST00000295863	H9KV32 [Direct mapping] Cell surface glycoprotein CD200 receptor 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	212 aa 23.8 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.