Tissue expression of CADPS - Summary - The Human Protein Atlas

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CADPS

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CADPS
Gene description	Ca++-dependent secretion activator
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (adrenal gland, cerebral cortex)
GTEx:	Tissue enhanced (cerebral cortex, hypothalamus, pituitary gland)
FANTOM5:	Tissue enhanced (cerebellum, pituitary gland)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmix expression in CNS, peripheral nerves in several tissues and endocrine cells in pancreas and gastrointestinal tract.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA059328
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (adrenal gland, cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex, hypothalamus, pituitary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum, pituitary gland)

GENE INFORMATION
Gene name	CADPS (HGNC Symbol)
Synonyms	CAPS, CAPS1, KIAA1121
Description	Ca++-dependent secretion activator (HGNC Symbol)
Entrez gene summary	This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]
Chromosome	3
Cytoband	p14.2
Chromosome location (bp)	62398346 - 62875389
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163618 (version 83.38)
Entrez gene	8618
UniProt	Q9ULU8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9ULU8
Antibodypedia	CADPS antibodies

PROTEIN BROWSER

CADPS-001	CADPS-002	CADPS-006	CADPS-008	CADPS-013	CADPS-015	CADPS-016	CADPS-017	CADPS-018	CADPS-201	CADPS-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CADPS-001 ENSP00000283269 ENST00000283269	Q9ULU8 [Direct mapping] Calcium-dependent secretion activator 1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006887 [exocytosis] GO:0008289 [lipid binding] GO:0015031 [protein transport] GO:0019901 [protein kinase binding] GO:0030054 [cell junction] GO:0030659 [cytoplasmic vesicle membrane] GO:0045202 [synapse] GO:0046872 [metal ion binding] Show all	1314 aa 148.8 kDa	No	0
CADPS-002 ENSP00000418736 ENST00000490353	Q9ULU8 [Direct mapping] Calcium-dependent secretion activator 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006887 [exocytosis] GO:0008289 [lipid binding] GO:0015031 [protein transport] GO:0019901 [protein kinase binding] GO:0030054 [cell junction] GO:0030659 [cytoplasmic vesicle membrane] GO:0045202 [synapse] GO:0046872 [metal ion binding] Show all	457 aa 50.2 kDa	No	0
CADPS-006 ENSP00000350632 ENST00000357948	Q9ULU8 [Direct mapping] Calcium-dependent secretion activator 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006887 [exocytosis] GO:0008289 [lipid binding] GO:0015031 [protein transport] GO:0019901 [protein kinase binding] GO:0030054 [cell junction] GO:0030659 [cytoplasmic vesicle membrane] GO:0045202 [synapse] GO:0046872 [metal ion binding] Show all	1274 aa 144.1 kDa	No	0
CADPS-008 ENSP00000417827 ENST00000468271	H7C4P2 [Direct mapping] Calcium-dependent secretion activator 1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		240 aa 27.3 kDa	No	0
CADPS-013 ENSP00000373215 ENST00000383710	Q9ULU8 [Direct mapping] Calcium-dependent secretion activator 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006887 [exocytosis] GO:0008289 [lipid binding] GO:0015031 [protein transport] GO:0016050 [vesicle organization] GO:0016082 [synaptic vesicle priming] GO:0019901 [protein kinase binding] GO:0030054 [cell junction] GO:0030659 [cytoplasmic vesicle membrane] GO:0031410 [cytoplasmic vesicle] GO:0045202 [synapse] GO:0046872 [metal ion binding] GO:0050432 [catecholamine secretion] Show all	1353 aa 152.8 kDa	No	0
CADPS-015 ENSP00000418889 ENST00000473635	H7C538 [Direct mapping] Calcium-dependent secretion activator 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		345 aa 39.5 kDa	No	0
CADPS-016 ENSP00000418110 ENST00000491424	H7C4T6 [Direct mapping] Calcium-dependent secretion activator 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		311 aa 35.8 kDa	No	0
CADPS-017 ENSP00000439528 ENST00000542833	H0YFP0 [Direct mapping] Calcium-dependent secretion activator 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		212 aa 24.2 kDa	No	0
CADPS-018 ENSP00000417568 ENST00000466621	H7C4K9 [Direct mapping] Calcium-dependent secretion activator 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		190 aa 22.1 kDa	No	0
CADPS-201 ENSP00000484365 ENST00000612439	F1T0E5 [Direct mapping] Calcium-dependent secretion activator 1 Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		1344 aa 152 kDa	No	0
CADPS-202 ENSP00000482556 ENST00000613879	A0A0C4DGY2 [Direct mapping] Calcium-dependent secretion activator 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		222 aa 25.7 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.