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A few cases of malignant melanomas displayed moderate cytoplasmic and occasional membranous positivity while renal cancers displayed cytoplasmic staining. Remaining malignant cells were negative.
A single case of carcinoid showed moderate nuclear positivity. Rare ovarian and breast cancers displayed weak to moderate staining in fraction of cells. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
NKX6-1 (HGNC Symbol)
Synonyms
Nkx6.1, NKX6A
Description
NK6 homeobox 1 (HGNC Symbol)
Entrez gene summary
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].[supplied by OMIM, Mar 2008]