Fields »
ABOUT
HELP
BLOG
CDS1

GENERAL INFORMATION

Gene name

 CDS1

Gene description

 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1

Protein class

 Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (CAPAN-2, hTCEpi, SK-BR-3)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA036187
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and colorectal cancer (favourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036187

GENE INFORMATION

Gene name

 CDS1

Synonyms

Description

 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 (HGNC Symbol)

Entrez gene summary

 Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q21.23

Chromosome location (bp)

 84582979 - 84651338

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163624 (version 83.38)

Entrez gene

 1040

UniProt

 Q92903 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q92903

Antibodypedia

 CDS1 antibodies

PROTEIN BROWSER
CDS1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDS1-001
ENSP00000295887
ENST00000295887
Q92903 [Direct mapping]
Phosphatidate cytidylyltransferase 1
A0A024RDG8 [Target identity:100%; Query identity:100%]
Phosphatidate cytidylyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004142 [diacylglycerol cholinephosphotransferase activity]
GO:0004605 [phosphatidate cytidylyltransferase activity]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006644 [phospholipid metabolic process]
GO:0006655 [phosphatidylglycerol biosynthetic process]
GO:0006657 [CDP-choline pathway]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0007165 [signal transduction]
GO:0007602 [phototransduction]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016024 [CDP-diacylglycerol biosynthetic process]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
Show all
 461 aa
53.3 kDa 		No 9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.