Tissue expression of GMPS - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	GMPS
Gene description	Guanine monophosphate synthase
Protein class	Cancer-related genes Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	GMPS
Synonyms
Description	Guanine monophosphate synthase (HGNC Symbol)
Entrez gene summary	In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q25.31
Chromosome location (bp)	155870536 - 155944026
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163655 (version 83.38)
Entrez gene	8833
UniProt	P49915 (UniProt - Evidence at protein level)
neXtProt	NX_P49915
Antibodypedia	GMPS antibodies

PROTEIN BROWSER

GMPS-001	GMPS-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GMPS-001 ENSP00000419851 ENST00000496455	P49915 [Direct mapping] GMP synthase [glutamine-hydrolyzing] Show all	Enzymes ENZYME proteins Ligase SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003921 [GMP synthase activity] GO:0003922 [GMP synthase (glutamine-hydrolyzing) activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006164 [purine nucleotide biosynthetic process] GO:0006177 [GMP biosynthetic process] GO:0006541 [glutamine metabolic process] GO:0009113 [purine nucleobase biosynthetic process] GO:0009168 [purine ribonucleoside monophosphate biosynthetic process] GO:0016462 [pyrophosphatase activity] GO:0044281 [small molecule metabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	693 aa 76.7 kDa	No	0
GMPS-002 ENSP00000295920 ENST00000295920	P49915 [Direct mapping] GMP synthase [glutamine-hydrolyzing] Show all	Enzymes ENZYME proteins Ligase SCAMPI predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003921 [GMP synthase activity] GO:0003922 [GMP synthase (glutamine-hydrolyzing) activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006164 [purine nucleotide biosynthetic process] GO:0006177 [GMP biosynthetic process] GO:0006541 [glutamine metabolic process] GO:0009113 [purine nucleobase biosynthetic process] GO:0009168 [purine ribonucleoside monophosphate biosynthetic process] GO:0016462 [pyrophosphatase activity] GO:0044281 [small molecule metabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	594 aa 65.9 kDa	No	0