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PTX3

GENERAL INFORMATION

Gene name

 PTX3

Gene description

 Pentraxin 3, long

Protein class

 Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (glioma)
HPA (cell line):Cell line enhanced (AF22, ASC TERT1, BJ hTERT+, TIME, U-2197)
HPA (normal tissue):Tissue enhanced (adipose tissue, appendix)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Extracellular deposits and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA069320
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable), lung cancer (unfavourable) and head and neck cancer (unfavourable).
Endometrial cancer p<0.001
Lung cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA069320

GENE INFORMATION

Gene name

 PTX3 (HGNC Symbol)

Synonyms

 TNFAIP5, TSG-14

Description

 Pentraxin 3, long (HGNC Symbol)

Entrez gene summary

Chromosome

 3

Cytoband

 q25.32

Chromosome location (bp)

 157436789 - 157443628

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163661 (version 83.38)

Entrez gene

 5806

UniProt

 P26022 (UniProt - Evidence at protein level)

neXtProt

 NX_P26022

Antibodypedia

 PTX3 antibodies

PROTEIN BROWSER
PTX3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTX3-001
ENSP00000295927
ENST00000295927
P26022 [Direct mapping]
Pentraxin-related protein PTX3
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001849 [complement component C1q binding]
GO:0001872 [(1->3)-beta-D-glucan binding]
GO:0001878 [response to yeast]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006954 [inflammatory response]
GO:0008228 [opsonization]
GO:0044869 [negative regulation by host of viral exo-alpha-sialidase activity]
GO:0044871 [negative regulation by host of viral glycoprotein metabolic process]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0046597 [negative regulation of viral entry into host cell]
GO:0046790 [virion binding]
GO:0050766 [positive regulation of phagocytosis]
GO:1903016 [negative regulation of exo-alpha-sialidase activity]
GO:1903019 [negative regulation of glycoprotein metabolic process]
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 381 aa
42 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.