Expression of DCLK3 in cancer - Summary - The Human Protein Atlas

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DCLK3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DCLK3
Gene description	Doublecortin-like kinase 3
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (testis cancer)
HPA (cell line):	Cell line enhanced (SCLC-21H)
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. External RNA characterization data suggests expression in tibial nerve.
Reliability score	Uncertain based on 1 antibody. CAB015207
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB015207

GENE INFORMATION
Gene name	DCLK3 (HGNC Symbol)
Synonyms	DCAMKL3, DCDC3C, KIAA1765
Description	Doublecortin-like kinase 3 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p22.2
Chromosome location (bp)	36712422 - 36739861
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163673 (version 83.38)
Entrez gene	85443
UniProt	Q9C098 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9C098
Antibodypedia	DCLK3 antibodies

PROTEIN BROWSER

DCLK3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DCLK3-001 ENSP00000394484 ENST00000416516	Q9C098 [Direct mapping] Serine/threonine-protein kinase DCLK3 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] Show all	648 aa 73.8 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.