Expression of ABHD6 in cancer - Summary - The Human Protein Atlas

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ABHD6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ABHD6
Gene description	Abhydrolase domain containing 6
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear membrane and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA017283
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and colorectal cancer (favourable).
Renal cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA017283

GENE INFORMATION
Gene name	ABHD6
Synonyms
Description	Abhydrolase domain containing 6 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p14.3
Chromosome location (bp)	58237506 - 58295693
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163686 (version 83.38)
Entrez gene	57406
UniProt	Q9BV23 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BV23
Antibodypedia	ABHD6 antibodies

PROTEIN BROWSER

ABHD6-001	ABHD6-002	ABHD6-004	ABHD6-005	ABHD6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABHD6-001 ENSP00000420315 ENST00000478253	Q9BV23 [Direct mapping] Monoacylglycerol lipase ABHD6 A0A024R323 [Target identity:100%; Query identity:100%] Abhydrolase domain containing 6, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004620 [phospholipase activity] GO:0005739 [mitochondrion] GO:0005886 [plasma membrane] GO:0007596 [blood coagulation] GO:0009395 [phospholipid catabolic process] GO:0016021 [integral component of membrane] GO:0030168 [platelet activation] GO:0030336 [negative regulation of cell migration] GO:0032281 [AMPA glutamate receptor complex] GO:0046464 [acylglycerol catabolic process] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0047372 [acylglycerol lipase activity] GO:0060292 [long term synaptic depression] GO:0070062 [extracellular exosome] GO:2000124 [regulation of endocannabinoid signaling pathway] Show all	337 aa 38.3 kDa	No	1
ABHD6-002 ENSP00000295962 ENST00000295962	Q9BV23 [Direct mapping] Monoacylglycerol lipase ABHD6 A0A024R323 [Target identity:100%; Query identity:100%] Abhydrolase domain containing 6, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004620 [phospholipase activity] GO:0005739 [mitochondrion] GO:0005886 [plasma membrane] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0030168 [platelet activation] GO:0046464 [acylglycerol catabolic process] GO:0047372 [acylglycerol lipase activity] GO:0070062 [extracellular exosome] Show all	337 aa 38.3 kDa	No	1
ABHD6-004 ENSP00000420408 ENST00000463756	C9JNE7 [Direct mapping] Monoacylglycerol lipase ABHD6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	225 aa 25.5 kDa	No	1
ABHD6-005 ENSP00000418934 ENST00000485900	C9J010 [Direct mapping] Monoacylglycerol lipase ABHD6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	173 aa 19.7 kDa	No	1
ABHD6-201 ENSP00000484876 ENST00000613521	A0A087X2C5 [Direct mapping] Monoacylglycerol lipase ABHD6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	318 aa 35.8 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.