Expression of DNASE1L3 in cancer - Summary - The Human Protein Atlas

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DNASE1L3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DNASE1L3
Gene description	Deoxyribonuclease I-like 3
Protein class	Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (BEWO, RPMI-8226)
HPA (normal tissue):	Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA019955
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and liver cancer (favourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA019955

GENE INFORMATION
Gene name	DNASE1L3 (HGNC Symbol)
Synonyms	DNAS1L3, LSD
Description	Deoxyribonuclease I-like 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Chromosome	3
Cytoband	p14.3
Chromosome location (bp)	58192257 - 58214697
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163687 (version 83.38)
Entrez gene	1776
UniProt	Q13609 (UniProt - Evidence at protein level)
neXtProt	NX_Q13609
Antibodypedia	DNASE1L3 antibodies

PROTEIN BROWSER

DNASE1L3-001	DNASE1L3-002	DNASE1L3-003	DNASE1L3-005	DNASE1L3-006	DNASE1L3-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DNASE1L3-001 ENSP00000378053 ENST00000394549	Q13609 [Direct mapping] Deoxyribonuclease gamma A0A024R365 [Target identity:100%; Query identity:100%] Deoxyribonuclease Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0004519 [endonuclease activity] GO:0004520 [endodeoxyribonuclease activity] GO:0004536 [deoxyribonuclease activity] GO:0005509 [calcium ion binding] GO:0005634 [nucleus] GO:0006259 [DNA metabolic process] GO:0006308 [DNA catabolic process] GO:0006309 [apoptotic DNA fragmentation] GO:0010623 [developmental programmed cell death] GO:0016888 [endodeoxyribonuclease activity, producing 5'-phosphomonoesters] Show all	305 aa 35.5 kDa	Yes	0
DNASE1L3-002 ENSP00000417047 ENST00000483681	A0A0A0MT68 [Direct mapping] Deoxyribonuclease Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004520 [endodeoxyribonuclease activity] GO:0004536 [deoxyribonuclease activity] GO:0005634 [nucleus] GO:0006308 [DNA catabolic process] GO:0006309 [apoptotic DNA fragmentation] GO:0016888 [endodeoxyribonuclease activity, producing 5'-phosphomonoesters] Show all	288 aa 33.6 kDa	Yes	0
DNASE1L3-003 ENSP00000418509 ENST00000460422	C9J0L2 [Direct mapping] Deoxyribonuclease gamma Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004520 [endodeoxyribonuclease activity] GO:0004536 [deoxyribonuclease activity] GO:0005634 [nucleus] GO:0006308 [DNA catabolic process] GO:0006309 [apoptotic DNA fragmentation] Show all	100 aa 11.6 kDa	Yes	0
DNASE1L3-005 ENSP00000419052 ENST00000486455	Q13609 [Direct mapping] Deoxyribonuclease gamma Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004520 [endodeoxyribonuclease activity] GO:0004536 [deoxyribonuclease activity] GO:0005509 [calcium ion binding] GO:0005634 [nucleus] GO:0006259 [DNA metabolic process] GO:0006308 [DNA catabolic process] GO:0006309 [apoptotic DNA fragmentation] GO:0016888 [endodeoxyribonuclease activity, producing 5'-phosphomonoesters] Show all	275 aa 31.9 kDa	Yes	0
DNASE1L3-006 ENSP00000417976 ENST00000477209	H7C4R7 [Direct mapping] Deoxyribonuclease gamma Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004520 [endodeoxyribonuclease activity] GO:0004536 [deoxyribonuclease activity] GO:0005634 [nucleus] GO:0006308 [DNA catabolic process] GO:0006309 [apoptotic DNA fragmentation] GO:0016888 [endodeoxyribonuclease activity, producing 5'-phosphomonoesters] Show all	137 aa 15.8 kDa	No	0
DNASE1L3-007 ENSP00000418113 ENST00000461914	C9J9N0 [Direct mapping] Deoxyribonuclease gamma Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004520 [endodeoxyribonuclease activity] GO:0004536 [deoxyribonuclease activity] GO:0005634 [nucleus] GO:0006308 [DNA catabolic process] GO:0006309 [apoptotic DNA fragmentation] Show all	158 aa 18.5 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
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