Expression of IL17RE in cancer - Summary - The Human Protein Atlas

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IL17RE

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IL17RE
Gene description	Interleukin 17 receptor E
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1, BEWO, T-47d)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and/or nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA019011
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA019011

GENE INFORMATION
Gene name	IL17RE (HGNC Symbol)
Synonyms	FLJ23658
Description	Interleukin 17 receptor E (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]
Chromosome	3
Cytoband	p25.3
Chromosome location (bp)	9902612 - 9916402
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163701 (version 83.38)
Entrez gene	132014
UniProt	Q8NFR9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NFR9
Antibodypedia	IL17RE antibodies

PROTEIN BROWSER

IL17RE-001	IL17RE-002	IL17RE-003	IL17RE-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL17RE-001 ENSP00000373325 ENST00000383814	Q8NFR9 [Direct mapping] Interleukin-17 receptor E Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0019221 [cytokine-mediated signaling pathway] GO:0030368 [interleukin-17 receptor activity] Show all	667 aa 74.8 kDa	Yes	1
IL17RE-002 ENSP00000404916 ENST00000421412	J3KQN7 [Direct mapping] Interleukin 17 receptor E, isoform CRA_c; Interleukin-17 receptor E Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005887 [integral component of plasma membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030368 [interleukin-17 receptor activity] Show all	700 aa 78.4 kDa	Yes	1
IL17RE-003 ENSP00000388086 ENST00000454190	Q8NFR9 [Direct mapping] Interleukin-17 receptor E Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0019221 [cytokine-mediated signaling pathway] GO:0030368 [interleukin-17 receptor activity] Show all	533 aa 58.1 kDa	Yes	0
IL17RE-010 ENSP00000400768 ENST00000454992	C9J1R2 [Direct mapping] Interleukin-17 receptor E Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005887 [integral component of plasma membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030368 [interleukin-17 receptor activity] Show all	173 aa 19.6 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.