Cell atlas - CRELD1 - The Human Protein Atlas

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CRELD1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli

Human cell
	Cytosol
	Nucleoli

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GENERAL INFORMATION
Gene name	CRELD1
Gene description	Cysteine-rich with EGF-like domains 1
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Additional location	In addition localized to the Nucleoli (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA026964
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the nucleoli.

Main location

Cytosol (approved)

Additional location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA026964	A-431	Cytosol
	HPA026964	U-2 OS	Nucleoli
	HPA026964	U-2 OS	Cytosol
	HPA026964	U-251 MG	Nucleoli
	HPA026964	U-251 MG	Cytosol

GENE INFORMATION
Gene name	CRELD1 (HGNC Symbol)
Synonyms	AVSD2
Description	Cysteine-rich with EGF-like domains 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a subfamily of epidermal growth factor-related proteins. The encoded protein is characterized by a cysteine-rich with epidermal growth factor-like domain. This protein may function as a cell adhesion molecule. Mutations in this gene are the cause of atrioventricular septal defect. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
Chromosome	3
Cytoband	p25.3
Chromosome location (bp)	9933822 - 9945413
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163703 (version 83.38)
Entrez gene	78987
UniProt	Q96HD1 (UniProt - Evidence at protein level)
neXtProt	NX_Q96HD1
Antibodypedia	CRELD1 antibodies

PROTEIN BROWSER

CRELD1-001	CRELD1-002	CRELD1-003	CRELD1-004	CRELD1-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRELD1-001 ENSP00000373322 ENST00000383811	Q96HD1 [Direct mapping] Cysteine-rich with EGF-like domain protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003197 [endocardial cushion development] GO:0003279 [cardiac septum development] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	420 aa 45.4 kDa	Yes	1
CRELD1-002 ENSP00000380355 ENST00000397170	Q96HD1 [Direct mapping] Cysteine-rich with EGF-like domain protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003197 [endocardial cushion development] GO:0003279 [cardiac septum development] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	420 aa 45.4 kDa	Yes	1
CRELD1-003 ENSP00000393643 ENST00000452070	Q96HD1 [Direct mapping] Cysteine-rich with EGF-like domain protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003197 [endocardial cushion development] GO:0003279 [cardiac septum development] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	420 aa 45.4 kDa	Yes	1
CRELD1-004 ENSP00000321856 ENST00000326434	Q96HD1 [Direct mapping] Cysteine-rich with EGF-like domain protein 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003197 [endocardial cushion development] GO:0003279 [cardiac septum development] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	422 aa 45.9 kDa	Yes	0
CRELD1-013 ENSP00000406556 ENST00000435417	H7C2L3 [Direct mapping] Cysteine-rich with EGF-like domain protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	100 aa 10.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.