Tissue expression of CXCL1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CXCL1
Gene description	Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
Protein class	Cancer-related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cervix, uterine, spleen)
GTEx:	Tissue enhanced (spleen)
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cervix, uterine, spleen)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	CXCL1 (HGNC Symbol)
Synonyms	FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1
Description	Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) (HGNC Symbol)
Entrez gene summary	This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]
Chromosome	4
Cytoband	q13.3
Chromosome location (bp)	73869393 - 73871242
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163739 (version 83.38)
Entrez gene	2919
UniProt	P09341 (UniProt - Evidence at protein level)
neXtProt	NX_P09341
Antibodypedia	CXCL1 antibodies

PROTEIN BROWSER

CXCL1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CXCL1-001 ENSP00000379110 ENST00000395761	P09341 [Direct mapping] Growth-regulated alpha protein GRO-alpha(4-73) GRO-alpha(5-73) GRO-alpha(6-73) Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0002690 [positive regulation of leukocyte chemotaxis] GO:0005102 [receptor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007399 [nervous system development] GO:0008009 [chemokine activity] GO:0008047 [enzyme activator activity] GO:0008083 [growth factor activity] GO:0008283 [cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0030036 [actin cytoskeleton organization] GO:0032496 [response to lipopolysaccharide] GO:0035556 [intracellular signal transduction] GO:0043085 [positive regulation of catalytic activity] GO:0045236 [CXCR chemokine receptor binding] GO:0060326 [cell chemotaxis] GO:0070098 [chemokine-mediated signaling pathway] Show all	107 aa 11.3 kDa	Yes	0