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CPA3

GENERAL INFORMATION

Gene name

 CPA3

Gene description

 Carboxypeptidase A3 (mast cell)

Protein class

 Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (HEL)
HPA (normal tissue):Tissue enhanced (gallbladder)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct cytoplasmic expression in a subset of immune cells in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA006479 , HPA008689 , CAB020712
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA006479
HPA008689
CAB020712

GENE INFORMATION

Gene name

 CPA3

Synonyms

Description

 Carboxypeptidase A3 (mast cell) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein is proteolytically processed to generate a mature protease that is released by mast cells and may be involved in the degradation of endogenous proteins and the inactivation of venom-associated peptides. Expression of this gene may be elevated in human asthma patients. [provided by RefSeq, Nov 2015]

Chromosome

 3

Cytoband

 q24

Chromosome location (bp)

 148865256 - 148897196

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163751 (version 83.38)

Entrez gene

 1359

UniProt

 P15088 (UniProt - Evidence at protein level)

neXtProt

 NX_P15088

Antibodypedia

 CPA3 antibodies

PROTEIN BROWSER
CPA3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CPA3-001
ENSP00000296046
ENST00000296046
P15088 [Direct mapping]
Mast cell carboxypeptidase A
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002002 [regulation of angiotensin levels in blood]
GO:0002003 [angiotensin maturation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0004180 [carboxypeptidase activity]
GO:0004181 [metallocarboxypeptidase activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0008270 [zinc ion binding]
GO:0030133 [transport vesicle]
GO:0030141 [secretory granule]
GO:0044267 [cellular protein metabolic process]
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 417 aa
48.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.