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FYCO1

GENERAL INFORMATION

Gene name

 FYCO1

Gene description

 FYVE and coiled-coil domain containing 1

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA035526
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035526

GENE INFORMATION

Gene name

 FYCO1 (HGNC Symbol)

Synonyms

 FLJ13335, ZFYVE7

Description

 FYVE and coiled-coil domain containing 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2). [provided by RefSeq, Dec 2011]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 45917899 - 45995824

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163820 (version 83.38)

Entrez gene

 79443

UniProt

 Q9BQS8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BQS8

Antibodypedia

 FYCO1 antibodies

PROTEIN BROWSER
FYCO1-001
FYCO1-003
FYCO1-006
FYCO1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FYCO1-001
ENSP00000296137
ENST00000296137
Q9BQS8 [Direct mapping]
FYVE and coiled-coil domain-containing protein 1
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005764 [lysosome]
GO:0005770 [late endosome]
GO:0005776 [autophagosome]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0046872 [metal ion binding]
GO:0072383 [plus-end-directed vesicle transport along microtubule]
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 1478 aa
167 kDa 		No 0
FYCO1-003
ENSP00000388136
ENST00000433878
H7BZ74 [Direct mapping]
FYVE and coiled-coil domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006810 [transport]
GO:0016021 [integral component of membrane]
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 267 aa
28.7 kDa 		No 0
FYCO1-006
ENSP00000398517
ENST00000438446
C9J2W6 [Direct mapping]
FYVE and coiled-coil domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006810 [transport]
GO:0016021 [integral component of membrane]
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 149 aa
16.7 kDa 		No 0
FYCO1-201
ENSP00000441178
ENST00000535325
Q9BQS8 [Direct mapping]
FYVE and coiled-coil domain-containing protein 1
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Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005764 [lysosome]
GO:0005770 [late endosome]
GO:0005776 [autophagosome]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0046872 [metal ion binding]
GO:0072383 [plus-end-directed vesicle transport along microtubule]
Show all
 1498 aa
168.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.