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CCR1

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GENERAL INFORMATION

Gene name

 CCR1

Gene description

 Chemokine (C-C motif) receptor 1

Protein class

 CD markers
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (Karpas-707, U-266/84, RPMI-8226)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Karpas-707, U-266/84, RPMI-8226)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CCR1 (HGNC Symbol)

Synonyms

 CD191, CKR-1, CMKBR1, MIP1aR, SCYAR1

Description

 Chemokine (C-C motif) receptor 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 46201709 - 46208396

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163823 (version 83.38)

Entrez gene

 1230

UniProt

 P32246 (UniProt - Evidence at protein level)

neXtProt

 NX_P32246

Antibodypedia

 CCR1 antibodies

PROTEIN BROWSER
CCR1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCR1-001
ENSP00000296140
ENST00000296140
P32246 [Direct mapping]
C-C chemokine receptor type 1
Q5U003 [Target identity:100%; Query identity:100%]
Chemokine (C-C motif) receptor 1; Chemokine (C-C motif) receptor 1, isoform CRA_a
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CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0002407 [dendritic cell chemotaxis]
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006887 [exocytosis]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007267 [cell-cell signaling]
GO:0009611 [response to wounding]
GO:0009897 [external side of plasma membrane]
GO:0010629 [negative regulation of gene expression]
GO:0016021 [integral component of membrane]
GO:0016493 [C-C chemokine receptor activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019957 [C-C chemokine binding]
GO:0030335 [positive regulation of cell migration]
GO:0030502 [negative regulation of bone mineralization]
GO:0035717 [chemokine (C-C motif) ligand 7 binding]
GO:0045672 [positive regulation of osteoclast differentiation]
GO:0051928 [positive regulation of calcium ion transport]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071791 [chemokine (C-C motif) ligand 5 binding]
GO:0090026 [positive regulation of monocyte chemotaxis]
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 355 aa
41.2 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.