Expression of YEATS2 in cancer - Summary - The Human Protein Atlas

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YEATS2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	YEATS2
Gene description	YEATS domain containing 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA045891
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045891

GENE INFORMATION
Gene name	YEATS2 (HGNC Symbol)
Synonyms	FLJ10201, FLJ12841, FLJ13308, KIAA1197
Description	YEATS domain containing 2 (HGNC Symbol)
Entrez gene summary	YEATS2 is a scaffolding subunit of the ADA2A (TADA2A; MIM 602276)-containing (ATAC) histone acetyltransferase complex (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]
Chromosome	3
Cytoband	q27.1
Chromosome location (bp)	183697818 - 183812625
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163872 (version 83.38)
Entrez gene	55689
UniProt	Q9ULM3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9ULM3
Antibodypedia	YEATS2 antibodies

PROTEIN BROWSER

YEATS2-001	YEATS2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
YEATS2-001 ENSP00000306983 ENST00000305135	Q9ULM3 [Direct mapping] YEATS domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex] GO:0006325 [chromatin organization] GO:0006355 [regulation of transcription, DNA-templated] GO:0017025 [TBP-class protein binding] GO:0043966 [histone H3 acetylation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0072686 [mitotic spindle] Show all	1422 aa 150.8 kDa	No	0
YEATS2-003 ENSP00000406477 ENST00000432781	H0Y6M6 [Direct mapping] YEATS domain-containing protein 2 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006355 [regulation of transcription, DNA-templated] Show all	219 aa 21.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.