Fields »
ABOUT
HELP
BLOG
MEAF6

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 MEAF6

Gene description

 MYST/Esa1-associated factor 6

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear bodies. In addition localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear bodies (supported)

Additional location

 In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA029599
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear bodies. In addition localized to the nucleoplasm.

Main location

 Nuclear bodies (supported)

Additional location

 Nucleoplasm (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA029599 A-431 Nucleoplasm
Nuclear bodies
HPA029599 U-2 OS Nucleoplasm
Nuclear bodies
Cytosol
HPA029599 U-251 MG Nucleoplasm
Nuclear bodies

GENE INFORMATION

Gene name

 MEAF6 (HGNC Symbol)

Synonyms

 C1orf149, CENP-28, Eaf6, FLJ11730, NY-SAR-91

Description

 MYST/Esa1-associated factor 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear protein involved in transcriptional activation. The encoded protein may form a component of several different histone acetyltransferase complexes. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Chromosome

 1

Cytoband

 p34.3

Chromosome location (bp)

 37492575 - 37514774

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163875 (version 83.38)

Entrez gene

 64769

UniProt

 Q9HAF1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HAF1

Antibodypedia

 MEAF6 antibodies

PROTEIN BROWSER
MEAF6-001
MEAF6-002
MEAF6-003
MEAF6-008
MEAF6-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MEAF6-001
ENSP00000296214
ENST00000296214
Q9HAF1 [Direct mapping]
Chromatin modification-related protein MEAF6
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0043968 [histone H2A acetylation]
GO:0043981 [histone H4-K5 acetylation]
GO:0043982 [histone H4-K8 acetylation]
GO:0043983 [histone H4-K12 acetylation]
GO:0044154 [histone H3-K14 acetylation]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
Show all
 191 aa
21.6 kDa 		No 0
MEAF6-002
ENSP00000362166
ENST00000373075
Q9HAF1 [Direct mapping]
Chromatin modification-related protein MEAF6
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0043968 [histone H2A acetylation]
GO:0043981 [histone H4-K5 acetylation]
GO:0043982 [histone H4-K8 acetylation]
GO:0043983 [histone H4-K12 acetylation]
GO:0044154 [histone H3-K14 acetylation]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
Show all
 201 aa
22.8 kDa 		No 0
MEAF6-003
ENSP00000362165
ENST00000373074
B1AK63 [Direct mapping]
Chromatin modification-related protein MEAF6; Chromosome 1 open reading frame 149, isoform CRA_f
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
Show all
 169 aa
19.2 kDa 		No 0
MEAF6-008
ENSP00000362164
ENST00000373073
Q9HAF1 [Direct mapping]
Chromatin modification-related protein MEAF6
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0043968 [histone H2A acetylation]
GO:0043981 [histone H4-K5 acetylation]
GO:0043982 [histone H4-K8 acetylation]
GO:0043983 [histone H4-K12 acetylation]
GO:0044154 [histone H3-K14 acetylation]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
Show all
 192 aa
21.7 kDa 		No 0
MEAF6-201
ENSP00000394966
ENST00000448519
Q9HAF1 [Direct mapping]
Chromatin modification-related protein MEAF6
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0043968 [histone H2A acetylation]
GO:0043981 [histone H4-K5 acetylation]
GO:0043982 [histone H4-K8 acetylation]
GO:0043983 [histone H4-K12 acetylation]
GO:0044154 [histone H3-K14 acetylation]
GO:0070776 [MOZ/MORF histone acetyltransferase complex]
Show all
 191 aa
21.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.