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KLF15

GENERAL INFORMATION

Gene name

 KLF15

Gene description

 Kruppel-like factor 15

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (liver cancer)
HPA (cell line):Cell line enhanced (BEWO, RPMI-8226)
HPA (normal tissue):Tissue enhanced (ovary)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular cytoplasmic expression in several tissues most abundant in renal tubules.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA028866
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA028866

GENE INFORMATION

Gene name

 KLF15 (HGNC Symbol)

Synonyms

 KKLF

Description

 Kruppel-like factor 15 (HGNC Symbol)

Entrez gene summary

Chromosome

 3

Cytoband

 q21.3

Chromosome location (bp)

 126342635 - 126357442

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163884 (version 83.38)

Entrez gene

 28999

UniProt

 Q9UIH9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UIH9

Antibodypedia

 KLF15 antibodies

PROTEIN BROWSER
KLF15-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KLF15-001
ENSP00000296233
ENST00000296233
Q9UIH9 [Direct mapping]
Krueppel-like factor 15
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
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GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0072112 [glomerular visceral epithelial cell differentiation]
GO:1901653 [cellular response to peptide]
GO:2000757 [negative regulation of peptidyl-lysine acetylation]
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 416 aa
44 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.