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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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RHO
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

RHO

Gene description

Rhodopsin

Protein class

Disease related genes
G-protein coupled receptors
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Not detected

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in outer segments of photoreceptor cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

External characterization data supports antibody staining but no internal RNA data available for correlation.

Reliability score

Supported based on 2 antibodies.
HPA013440 , CAB022486
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Not detected
0.0200m400m600m800m1.01.21.41.61.82.02.22.42.62.8FPKMBreast cancer (BRCA)Cervical cancer (CESC)Colorectal cancer (COAD,READ)Endometrial cancer (UCEC)Glioma (GBM)Head and neck cancer (HNSC)Liver cancer (LIHC)Lung cancer (LUAD,LUSC)Melanoma (SKCM)Ovarian cancer (OV)Pancreatic cancer (PAAD)Prostate cancer (PRAD)Renal cancer (KICH,KIRC,KIRP)Stomach cancer (STAD)Testis cancer (TGCT)Thyroid cancer (THCA)Urothelial cancer (BLCA)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA013440
CAB022486

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

All cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A fraction of cells in basal layer of skin showed cytoplasmic staining. The remaining normal and all malignant tissues were negative.

GENE INFORMATION

Gene name

RHO (HGNC Symbol)

Synonyms

CSNBAD1, OPN2, RP4

Description

Rhodopsin (HGNC Symbol)

Entrez gene summary

Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

q22.1

Chromosome location (bp)

129528640 - 129535169

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163914 (version 83.38)

Entrez gene

6010

UniProt

P08100 (UniProt - Evidence at protein level)

neXtProt

NX_P08100

Antibodypedia

RHO antibodies

PROTEIN BROWSER

RHO-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RHO-001
ENSP00000296271
ENST00000296271
P08100 [Direct mapping]
Rhodopsin
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Opsins
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001523 [retinoid metabolic process]
GO:0001750 [photoreceptor outer segment]
GO:0001917 [photoreceptor inner segment]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006468 [protein phosphorylation]
GO:0006996 [organelle organization]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007601 [visual perception]
GO:0007602 [phototransduction]
GO:0007603 [phototransduction, visible light]
GO:0009416 [response to light stimulus]
GO:0009583 [detection of light stimulus]
GO:0009585 [red, far-red light phototransduction]
GO:0009881 [photoreceptor activity]
GO:0016021 [integral component of membrane]
GO:0016038 [absorption of visible light]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0016918 [retinal binding]
GO:0018298 [protein-chromophore linkage]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0030660 [Golgi-associated vesicle membrane]
GO:0030867 [rough endoplasmic reticulum membrane]
GO:0042622 [photoreceptor outer segment membrane]
GO:0045494 [photoreceptor cell maintenance]
GO:0046872 [metal ion binding]
GO:0050953 [sensory perception of light stimulus]
GO:0060041 [retina development in camera-type eye]
GO:0060170 [ciliary membrane]
GO:0060342 [photoreceptor inner segment membrane]
GO:0071482 [cellular response to light stimulus]
GO:0097381 [photoreceptor disc membrane]
Show all
348 aa
38.9 kDa
No 7

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