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RHO

GENERAL INFORMATION

Gene name

 RHO

Gene description

 Rhodopsin

Protein class

 Disease related genes
G-protein coupled receptors
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Not detected

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in outer segments of photoreceptor cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 External characterization data supports antibody staining but no internal RNA data available for correlation.

Reliability score

 Supported based on 2 antibodies.
HPA013440 , CAB022486
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA013440
CAB022486

GENE INFORMATION

Gene name

 RHO (HGNC Symbol)

Synonyms

 CSNBAD1, OPN2, RP4

Description

 Rhodopsin (HGNC Symbol)

Entrez gene summary

 Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q22.1

Chromosome location (bp)

 129528640 - 129535169

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163914 (version 83.38)

Entrez gene

 6010

UniProt

 P08100 (UniProt - Evidence at protein level)

neXtProt

 NX_P08100

Antibodypedia

 RHO antibodies

PROTEIN BROWSER
RHO-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RHO-001
ENSP00000296271
ENST00000296271
P08100 [Direct mapping]
Rhodopsin
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Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Opsins
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
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GO:0000139 [Golgi membrane]
GO:0001523 [retinoid metabolic process]
GO:0001750 [photoreceptor outer segment]
GO:0001917 [photoreceptor inner segment]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006468 [protein phosphorylation]
GO:0006996 [organelle organization]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007601 [visual perception]
GO:0007602 [phototransduction]
GO:0007603 [phototransduction, visible light]
GO:0009416 [response to light stimulus]
GO:0009583 [detection of light stimulus]
GO:0009585 [red, far-red light phototransduction]
GO:0009881 [photoreceptor activity]
GO:0016021 [integral component of membrane]
GO:0016038 [absorption of visible light]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0016918 [retinal binding]
GO:0018298 [protein-chromophore linkage]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0030660 [Golgi-associated vesicle membrane]
GO:0030867 [rough endoplasmic reticulum membrane]
GO:0042622 [photoreceptor outer segment membrane]
GO:0045494 [photoreceptor cell maintenance]
GO:0046872 [metal ion binding]
GO:0050953 [sensory perception of light stimulus]
GO:0060041 [retina development in camera-type eye]
GO:0060170 [ciliary membrane]
GO:0060342 [photoreceptor inner segment membrane]
GO:0071482 [cellular response to light stimulus]
GO:0097381 [photoreceptor disc membrane]
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 348 aa
38.9 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.