Expression of RFT1 in cancer - Summary - The Human Protein Atlas

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RFT1

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	RFT1
Gene description	RFT1 homolog
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	RFT1 (HGNC Symbol)
Synonyms	CDG1N
Description	RFT1 homolog (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme which catalyzes the translocation of the Man(5)GlcNAc (2)-PP-Dol intermediate from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane in the pathway for the N-glycosylation of proteins. Mutations in this gene are associated with congenital disorder of glycosylation type In.[provided by RefSeq, Dec 2008]
Chromosome	3
Cytoband	p21.1
Chromosome location (bp)	53088483 - 53130462
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163933 (version 83.38)
Entrez gene	91869
UniProt	Q96AA3 (UniProt - Evidence at protein level)
neXtProt	NX_Q96AA3
Antibodypedia	RFT1 antibodies

PROTEIN BROWSER

RFT1-001	RFT1-002	RFT1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RFT1-001 ENSP00000296292 ENST00000296292	Q96AA3 [Direct mapping] Protein RFT1 homolog Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005319 [lipid transporter activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006869 [lipid transport] GO:0008643 [carbohydrate transport] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0034203 [glycolipid translocation] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	541 aa 60.3 kDa	No	>9
RFT1-002 ENSP00000378223 ENST00000394738	B5MDE0 [Direct mapping] Protein RFT1 homolog; RFT1 homolog (S. cerevisiae), isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005319 [lipid transporter activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006869 [lipid transport] GO:0016021 [integral component of membrane] GO:0034203 [glycolipid translocation] Show all	502 aa 55.8 kDa	No	>9
RFT1-005 ENSP00000420325 ENST00000467048	C9JP01 [Direct mapping] Protein RFT1 homolog Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005319 [lipid transporter activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006869 [lipid transport] GO:0016021 [integral component of membrane] GO:0034203 [glycolipid translocation] Show all	292 aa 33 kDa	No	5

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.