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GNL3

GENERAL INFORMATION

Gene name

 GNL3

Gene description

 Guanine nucleotide binding protein-like 3 (nucleolar)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nucleolar expression in all tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA036742 , HPA036743 , CAB020770
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GNL3 (HGNC Symbol)

Synonyms

 C77032, E2IG3, MGC800, NS

Description

 Guanine nucleotide binding protein-like 3 (nucleolar) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Chromosome

 3

Cytoband

 p21.1

Chromosome location (bp)

 52681156 - 52694492

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163938 (version 83.38)

Entrez gene

 26354

UniProt

 Q9BVP2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BVP2

Antibodypedia

 GNL3 antibodies

PROTEIN BROWSER
GNL3-001
GNL3-002
GNL3-008
GNL3-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNL3-001
ENSP00000395772
ENST00000418458
Q9BVP2 [Direct mapping]
Guanine nucleotide-binding protein-like 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0042127 [regulation of cell proliferation]
GO:0042254 [ribosome biogenesis]
GO:0044822 [poly(A) RNA binding]
GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]
Show all
 549 aa
62 kDa 		No 0
GNL3-002
ENSP00000378278
ENST00000394799
Q9BVP2 [Direct mapping]
Guanine nucleotide-binding protein-like 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0016020 [membrane]
GO:0042127 [regulation of cell proliferation]
GO:0042254 [ribosome biogenesis]
GO:0044822 [poly(A) RNA binding]
GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]
Show all
 537 aa
60.5 kDa 		No 0
GNL3-008
ENSP00000419895
ENST00000474423
C9JYH9 [Direct mapping]
Guanine nucleotide-binding protein-like 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005730 [nucleolus]
GO:0042254 [ribosome biogenesis]
Show all
 96 aa
11.7 kDa 		No 0
GNL3-011
ENSP00000419734
ENST00000479230
C9JZT7 [Direct mapping]
Guanine nucleotide-binding protein-like 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005730 [nucleolus]
GO:0042254 [ribosome biogenesis]
Show all
 135 aa
16 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.