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ARHGEF3

GENERAL INFORMATION

Gene name

 ARHGEF3

Gene description

 Rho guanine nucleotide exchange factor (GEF) 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (Hep G2, RPMI-8226)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA034715
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), endometrial cancer (favourable) and head and neck cancer (favourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA034715

GENE INFORMATION

Gene name

 ARHGEF3 (HGNC Symbol)

Synonyms

 DKFZP434F2429, GEF3, STA3, XPLN

Description

 Rho guanine nucleotide exchange factor (GEF) 3 (HGNC Symbol)

Entrez gene summary

 Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p14.3

Chromosome location (bp)

 56727418 - 57079329

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163947 (version 83.38)

Entrez gene

 50650

UniProt

 Q9NR81 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NR81

Antibodypedia

 ARHGEF3 antibodies

PROTEIN BROWSER
ARHGEF3-001
ARHGEF3-002
ARHGEF3-003
ARHGEF3-005
ARHGEF3-006
ARHGEF3-007
ARHGEF3-008
ARHGEF3-010
ARHGEF3-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGEF3-001
ENSP00000296315
ENST00000296315
Q9NR81 [Direct mapping]
Rho guanine nucleotide exchange factor 3
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Predicted intracellular proteins
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GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
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 526 aa
59.8 kDa 		No 0
ARHGEF3-002
ENSP00000341071
ENST00000338458
Q9NR81 [Direct mapping]
Rho guanine nucleotide exchange factor 3
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Predicted intracellular proteins
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
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 558 aa
63.8 kDa 		No 0
ARHGEF3-003
ENSP00000410922
ENST00000413728
Q9NR81 [Direct mapping]
Rho guanine nucleotide exchange factor 3
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
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 532 aa
60.8 kDa 		No 0
ARHGEF3-005
ENSP00000418826
ENST00000497267
E7EU49 [Direct mapping]
Rho guanine nucleotide exchange factor 3
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Predicted intracellular proteins
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005622 [intracellular]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
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 497 aa
56.7 kDa 		No 0
ARHGEF3-006
ENSP00000417986
ENST00000495373
C9J586 [Direct mapping]
Rho guanine nucleotide exchange factor 3
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Predicted intracellular proteins
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005622 [intracellular]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
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 416 aa
47.6 kDa 		No 0
ARHGEF3-007
ENSP00000420420
ENST00000496106
E9PG37 [Direct mapping]
Rho guanine nucleotide exchange factor 3
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Predicted intracellular proteins
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005622 [intracellular]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 532 aa
60.8 kDa 		No 0
ARHGEF3-008
ENSP00000417087
ENST00000468727
C9J609 [Direct mapping]
Rho guanine nucleotide exchange factor 3
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Predicted intracellular proteins
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GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
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 184 aa
21.1 kDa 		No 0
ARHGEF3-010
ENSP00000420402
ENST00000473779
C9JNF2 [Direct mapping]
Rho guanine nucleotide exchange factor 3
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Predicted intracellular proteins
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 196 aa
22.7 kDa 		No 0
ARHGEF3-011
ENSP00000418469
ENST00000468466
C9J5K8 [Direct mapping]
Rho guanine nucleotide exchange factor 3
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Predicted intracellular proteins
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 100 aa
11.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.