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SLBP

GENERAL INFORMATION

Gene name

 SLBP

Gene description

 Stem-loop binding protein

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA019254
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019254

GENE INFORMATION

Gene name

 SLBP (HGNC Symbol)

Synonyms

 HBP

Description

 Stem-loop binding protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p16.3

Chromosome location (bp)

 1692800 - 1712555

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163950 (version 83.38)

Entrez gene

 7884

UniProt

 Q14493 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14493

Antibodypedia

 SLBP antibodies

PROTEIN BROWSER
SLBP-001
SLBP-002
SLBP-003
SLBP-004
SLBP-006
SLBP-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLBP-001
ENSP00000417686
ENST00000489418
Q14493 [Direct mapping]
Histone RNA hairpin-binding protein
Q53XR2 [Target identity:100%; Query identity:100%]
Stem-loop (Histone) binding protein; Stem-loop (Histone) binding protein, isoform CRA_b; cDNA, FLJ96722, Homo sapiens stem-loop (histone) binding protein (SLBP), mRNA
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006398 [histone mRNA 3'-end processing]
GO:0006406 [mRNA export from nucleus]
GO:0008334 [histone mRNA metabolic process]
GO:0010467 [gene expression]
GO:0030529 [ribonucleoprotein complex]
GO:0031124 [mRNA 3'-end processing]
GO:0033260 [nuclear DNA replication]
GO:0044822 [poly(A) RNA binding]
GO:0051028 [mRNA transport]
GO:0071204 [histone pre-mRNA 3'end processing complex]
GO:0071207 [histone pre-mRNA stem-loop binding]
GO:0071208 [histone pre-mRNA DCP binding]
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 270 aa
31.3 kDa 		No 0
SLBP-002
ENSP00000406322
ENST00000429429
Q14493 [Direct mapping]
Histone RNA hairpin-binding protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006398 [histone mRNA 3'-end processing]
GO:0006406 [mRNA export from nucleus]
GO:0008334 [histone mRNA metabolic process]
GO:0010467 [gene expression]
GO:0030529 [ribonucleoprotein complex]
GO:0031124 [mRNA 3'-end processing]
GO:0033260 [nuclear DNA replication]
GO:0044822 [poly(A) RNA binding]
GO:0051028 [mRNA transport]
GO:0071204 [histone pre-mRNA 3'end processing complex]
GO:0071207 [histone pre-mRNA stem-loop binding]
GO:0071208 [histone pre-mRNA DCP binding]
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 231 aa
26.7 kDa 		No 0
SLBP-003
ENSP00000418658
ENST00000488267
E7EUV9 [Direct mapping]
Histone RNA hairpin-binding protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
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 235 aa
27.3 kDa 		No 0
SLBP-004
ENSP00000316490
ENST00000318386
F8W8D3 [Direct mapping]
Histone RNA hairpin-binding protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
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 277 aa
32.1 kDa 		No 0
SLBP-006
ENSP00000417359
ENST00000480936
H7C4H8 [Direct mapping]
Histone RNA hairpin-binding protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
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 186 aa
21.2 kDa 		No 0
SLBP-007
ENSP00000426891
ENST00000483348
H0YAE8 [Direct mapping]
Histone RNA hairpin-binding protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
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 225 aa
26.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.