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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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LRPAP1
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

LRPAP1

Gene description

Low density lipoprotein receptor-related protein associated protein 1

Protein class

Disease related genes
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA008001 , CAB025518
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA008001
CAB025518

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues displayed moderate to strong cytoplasmic staining. Lymphomas and prostate cancers were in general negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancers showed moderate cytoplasmic staining. Melanomas and colorectal cancers displayed strong immunoreactivity.

GENE INFORMATION

Gene name

LRPAP1 (HGNC Symbol)

Synonyms

A2MRAP, HBP44

Description

Low density lipoprotein receptor-related protein associated protein 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Chromosome

4

Cytoband

p16.3

Chromosome location (bp)

3506376 - 3532559

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163956 (version 83.38)

Entrez gene

4043

UniProt

P30533 (UniProt - Evidence at protein level)

neXtProt

NX_P30533

Antibodypedia

LRPAP1 antibodies

PROTEIN BROWSER

LRPAP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LRPAP1-001
ENSP00000421922
ENST00000500728
P30533 [Direct mapping]
Alpha-2-macroglobulin receptor-associated protein
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004873 [asialoglycoprotein receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0006898 [receptor-mediated endocytosis]
GO:0008201 [heparin binding]
GO:0009986 [cell surface]
GO:0010916 [negative regulation of very-low-density lipoprotein particle clearance]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0031982 [vesicle]
GO:0032091 [negative regulation of protein binding]
GO:0035473 [lipase binding]
GO:0048019 [receptor antagonist activity]
GO:0048237 [rough endoplasmic reticulum lumen]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:0051082 [unfolded protein binding]
GO:0070326 [very-low-density lipoprotein particle receptor binding]
GO:1900116 [extracellular negative regulation of signal transduction]
GO:1900222 [negative regulation of beta-amyloid clearance]
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357 aa
41.5 kDa
Yes 0

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