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Weak to moderate cytoplasmic positivity was observed in most cancer cells. Mucinous ovarian cancers and adenocarcinomas in cervix showed strong staining. A majority of cases in lymphomas, cervical squamous cell carcinomas, urothelial and renal cancers were negative.
GENE INFORMATION
Gene name
PIGX (HGNC Symbol)
Synonyms
FLJ20522
Description
Phosphatidylinositol glycan anchor biosynthesis, class X (HGNC Symbol)
Entrez gene summary
This gene encodes a type I transmembrane protein in the endoplasmic reticulum (ER). The protein is an essential component of glycosylphosphatidylinositol-mannosyltransferase I, which transfers the first of the four mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Studies in rat indicate that the protein is translated from a non-AUG translation initiation site. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Q8TBF5 [Direct mapping] Phosphatidylinositol-glycan biosynthesis class X protein
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006506 [GPI anchor biosynthetic process] GO:0016021 [integral component of membrane] GO:0016254 [preassembly of GPI anchor in ER membrane] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process]