Expression of OTOP1 in cancer - Summary - The Human Protein Atlas

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OTOP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	OTOP1
Gene description	Otopetrin 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Not detected

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. No internal RNA expression data available for correlation.
Reliability score	Uncertain based on 1 antibody. HPA035599
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035599

GENE INFORMATION
Gene name	OTOP1
Synonyms
Description	Otopetrin 1 (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	4188803 - 4226889
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000163982 (version 83.38)
Entrez gene	133060
UniProt	Q7RTM1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q7RTM1
Antibodypedia	OTOP1 antibodies

PROTEIN BROWSER

OTOP1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OTOP1-001 ENSP00000296358 ENST00000296358	Q7RTM1 [Direct mapping] Otopetrin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005615 [extracellular space] GO:0016021 [integral component of membrane] GO:0031214 [biomineral tissue development] Show all	612 aa 67.4 kDa	No	>9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.