Expression of OTOP1 in cancer - Summary - The Human Protein Atlas

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OTOP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	OTOP1
Gene description	Otopetrin 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Not detected

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. No internal RNA expression data available for correlation.
Reliability score	Uncertain based on 1 antibody. HPA035599
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035599

Cancer	Cancer staining
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Cancer cells generally displayed moderate cytoplasmic positivity. A few cases of gliomas, endometrial and testicular cancers exhibited strong immunoreactivity. Most lymphomas were weakly stained or negative.

GENE INFORMATION
Gene name	OTOP1
Synonyms
Description	Otopetrin 1 (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	4188803 - 4226889
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000163982 (version 83.38)
Entrez gene	133060
UniProt	Q7RTM1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q7RTM1
Antibodypedia	OTOP1 antibodies

PROTEIN BROWSER

OTOP1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OTOP1-001 ENSP00000296358 ENST00000296358	Q7RTM1 [Direct mapping] Otopetrin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005615 [extracellular space] GO:0016021 [integral component of membrane] GO:0031214 [biomineral tissue development] Show all	612 aa 67.4 kDa	No	>9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.