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AIMP1

GENERAL INFORMATION

Gene name

 AIMP1

Gene description

 Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression. High expression in neuronal cells and pancreas.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA018476 , CAB017618
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable).
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA018476
CAB017618

GENE INFORMATION

Gene name

 AIMP1 (HGNC Symbol)

Synonyms

 EMAP-2, EMAPII, p43, SCYE1

Description

 Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]

Chromosome

 4

Cytoband

 q24

Chromosome location (bp)

 106315544 - 106349226

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164022 (version 83.38)

Entrez gene

 9255

UniProt

 Q12904 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12904

Antibodypedia

 AIMP1 antibodies

PROTEIN BROWSER
AIMP1-001
AIMP1-002
AIMP1-004
AIMP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AIMP1-001
ENSP00000378191
ENST00000394701
Q12904 [Direct mapping]
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 Endothelial monocyte-activating polypeptide 2
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0001525 [angiogenesis]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006006 [glucose metabolic process]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006915 [apoptotic process]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0009611 [response to wounding]
GO:0009986 [cell surface]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0017101 [aminoacyl-tRNA synthetase multienzyme complex]
GO:0030133 [transport vesicle]
GO:0042803 [protein homodimerization activity]
GO:0048514 [blood vessel morphogenesis]
GO:0050900 [leukocyte migration]
GO:0051020 [GTPase binding]
GO:0051607 [defense response to virus]
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 336 aa
37 kDa 		No 0
AIMP1-002
ENSP00000350699
ENST00000358008
Q12904 [Direct mapping]
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 Endothelial monocyte-activating polypeptide 2
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0001525 [angiogenesis]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006006 [glucose metabolic process]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006915 [apoptotic process]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0009611 [response to wounding]
GO:0009986 [cell surface]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0017101 [aminoacyl-tRNA synthetase multienzyme complex]
GO:0030133 [transport vesicle]
GO:0042803 [protein homodimerization activity]
GO:0050900 [leukocyte migration]
GO:0051020 [GTPase binding]
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 312 aa
34.4 kDa 		No 0
AIMP1-004
ENSP00000423681
ENST00000510207
D6R937 [Direct mapping]
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005829 [cytosol]
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 150 aa
16.6 kDa 		No 0
AIMP1-201
ENSP00000405248
ENST00000442366
Q12904 [Direct mapping]
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 Endothelial monocyte-activating polypeptide 2
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0001525 [angiogenesis]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006006 [glucose metabolic process]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006915 [apoptotic process]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0009611 [response to wounding]
GO:0009986 [cell surface]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0017101 [aminoacyl-tRNA synthetase multienzyme complex]
GO:0030133 [transport vesicle]
GO:0042803 [protein homodimerization activity]
GO:0050900 [leukocyte migration]
GO:0051020 [GTPase binding]
Show all
 312 aa
34.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.