Expression of EMCN in cancer - Summary - The Human Protein Atlas

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EMCN

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	EMCN
Gene description	Endomucin
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enriched (HUVEC TERT2)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA005928
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable) and renal cancer (favourable).
Liver cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA005928

GENE INFORMATION
Gene name	EMCN (HGNC Symbol)
Synonyms	MUC14
Description	Endomucin (HGNC Symbol)
Entrez gene summary	EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix (Kinoshita et al., 2001 [PubMed 11418125]).[supplied by OMIM, Mar 2008]
Chromosome	4
Cytoband	q24
Chromosome location (bp)	100395341 - 100880126
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164035 (version 83.38)
Entrez gene	51705
UniProt	Q9ULC0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9ULC0
Antibodypedia	EMCN antibodies

PROTEIN BROWSER

EMCN-001	EMCN-002	EMCN-003	EMCN-006	EMCN-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EMCN-001 ENSP00000296420 ENST00000296420	Q9ULC0 [Direct mapping] Endomucin Q4W5J1 [Target identity:100%; Query identity:100%] Endomucin, isoform CRA_a; Putative uncharacterized protein EMCN; cDNA, FLJ94060, Homo sapiens endomucin (EMCN), mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	261 aa 27.5 kDa	Yes	1
EMCN-002 ENSP00000422432 ENST00000511970	Q9ULC0 [Direct mapping] Endomucin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	248 aa 26.1 kDa	Yes	1
EMCN-003 ENSP00000304780 ENST00000305864	Q9ULC0 [Direct mapping] Endomucin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	178 aa 18.8 kDa	Yes	0
EMCN-006 ENSP00000427608 ENST00000502569	D6RHW5 [Direct mapping] Endomucin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	165 aa 17.5 kDa	Yes	1
EMCN-007 ENSP00000426515 ENST00000506300	H0YAA7 [Direct mapping] Endomucin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		76 aa 8.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.