Cell atlas - SLC9B1 - The Human Protein Atlas

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SLC9B1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	SLC9B1
Gene description	Solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA058971 , HPA065520
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA058971	SH-SY5Y	Mitochondria
	HPA058971	U-2 OS	No staining
	HPA065520	SH-SY5Y	Mitochondria
	HPA065520	U-2 OS	Mitochondria

GENE INFORMATION
Gene name	SLC9B1 (HGNC Symbol)
Synonyms	NHA1, NHEDC1
Description	Solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a sodium/hydrogen exchanger and transmembrane protein. Highly conserved orthologs of this gene have been found in other mammalian species. The expression of this gene may be limited to testis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Chromosome	4
Cytoband	q24
Chromosome location (bp)	102885048 - 103019739
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164037 (version 83.38)
Entrez gene	150159
UniProt	Q4ZJI4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q4ZJI4
Antibodypedia	SLC9B1 antibodies

PROTEIN BROWSER

SLC9B1-001	SLC9B1-002	SLC9B1-006	SLC9B1-007	SLC9B1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC9B1-001 ENSP00000296422 ENST00000296422	Q4ZJI4 [Direct mapping] Sodium/hydrogen exchanger 9B1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0015299 [solute:proton antiporter activity] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	515 aa 56.1 kDa	No	>9
SLC9B1-002 ENSP00000378269 ENST00000394789	Q4ZJI4 [Direct mapping] Sodium/hydrogen exchanger 9B1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0015299 [solute:proton antiporter activity] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	475 aa 52.2 kDa	No	>9
SLC9B1-006 ENSP00000426325 ENST00000510559	D6RGI9 [Direct mapping] Sodium/hydrogen exchanger 9B1 Show all	Predicted intracellular proteins Show all		50 aa 5.7 kDa	No	0
SLC9B1-007 ENSP00000425544 ENST00000511253	H0Y9Z0 [Direct mapping] Sodium/hydrogen exchanger 9B1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0006812 [cation transport] GO:0015299 [solute:proton antiporter activity] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	127 aa 13.6 kDa	No	3
SLC9B1-008 ENSP00000426056 ENST00000514340	D6RHJ0 [Direct mapping] Sodium/hydrogen exchanger 9B1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0006812 [cation transport] GO:0015299 [solute:proton antiporter activity] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	254 aa 27.8 kDa	No	6

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.