Expression of SLC9B2 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

SLC9B2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC9B2
Gene description	Solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous and cytoplasmic expression in most cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA047008
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047008

GENE INFORMATION
Gene name	SLC9B2 (HGNC Symbol)
Synonyms	FLJ23984, NHA2, NHEDC2
Description	Solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 (HGNC Symbol)
Entrez gene summary	Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007 [PubMed 18000046]).[supplied by OMIM, Mar 2008]
Chromosome	4
Cytoband	q24
Chromosome location (bp)	103019868 - 103085829
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164038 (version 83.38)
Entrez gene	133308
UniProt	Q86UD5 (UniProt - Evidence at protein level)
neXtProt	NX_Q86UD5
Antibodypedia	SLC9B2 antibodies

PROTEIN BROWSER

SLC9B2-001	SLC9B2-002	SLC9B2-003	SLC9B2-004	SLC9B2-006	SLC9B2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC9B2-001 ENSP00000378265 ENST00000394785	Q86UD5 [Direct mapping] Mitochondrial sodium/hydrogen exchanger 9B2 A0A024RDJ7 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0006812 [cation transport] GO:0006814 [sodium ion transport] GO:0015299 [solute:proton antiporter activity] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	537 aa 57.6 kDa	No	>9
SLC9B2-002 ENSP00000354574 ENST00000362026	Q86UD5 [Direct mapping] Mitochondrial sodium/hydrogen exchanger 9B2 A0A024RDJ7 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005743 [mitochondrial inner membrane] GO:0006812 [cation transport] GO:0006814 [sodium ion transport] GO:0015299 [solute:proton antiporter activity] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	537 aa 57.6 kDa	No	>9
SLC9B2-003 ENSP00000422477 ENST00000503230	E9PE63 [Direct mapping] Mitochondrial sodium/hydrogen exchanger 9B2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Show all	GO:0006812 [cation transport] GO:0006814 [sodium ion transport] GO:0015299 [solute:proton antiporter activity] GO:0016021 [integral component of membrane] GO:0031966 [mitochondrial membrane] GO:0055085 [transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	480 aa 51.5 kDa	No	9
SLC9B2-004 ENSP00000425385 ENST00000503103	B7Z676 [Direct mapping] Mitochondrial sodium/hydrogen exchanger 9B2; cDNA FLJ50743 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0006812 [cation transport] GO:0006814 [sodium ion transport] GO:0015299 [solute:proton antiporter activity] GO:0016021 [integral component of membrane] GO:0031966 [mitochondrial membrane] GO:0055085 [transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	417 aa 45.1 kDa	No	6
SLC9B2-006 ENSP00000421943 ENST00000506288	A0A0C4DGB3 [Direct mapping] Mitochondrial sodium/hydrogen exchanger 9B2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0006812 [cation transport] GO:0006814 [sodium ion transport] GO:0015299 [solute:proton antiporter activity] GO:0016021 [integral component of membrane] GO:0031966 [mitochondrial membrane] GO:0055085 [transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	354 aa 37.5 kDa	No	8
SLC9B2-007 ENSP00000426305 ENST00000503818	D6RGJ7 [Direct mapping] Mitochondrial sodium/hydrogen exchanger 9B2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0006814 [sodium ion transport] GO:0016021 [integral component of membrane] GO:0031966 [mitochondrial membrane] Show all	143 aa 15.7 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.