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ATRIP

GENERAL INFORMATION

Gene name

 ATRIP

Gene description

 ATR interacting protein

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
CAB033109
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB033109

GENE INFORMATION

Gene name

 ATRIP (HGNC Symbol)

Synonyms

 FLJ12343, MGC20625, MGC21482, MGC26740

Description

 ATR interacting protein (HGNC Symbol)

Entrez gene summary

 This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 48446710 - 48465716

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164053 (version 83.38)

Entrez gene

 84126

UniProt

 Q8WXE1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WXE1

Antibodypedia

 ATRIP antibodies

PROTEIN BROWSER
ATRIP-001
ATRIP-002
ATRIP-005
ATRIP-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATRIP-001
ENSP00000323099
ENST00000320211
Q8WXE1 [Direct mapping]
ATR-interacting protein
A0A024R2U4 [Target identity:100%; Query identity:100%]
Three prime repair exonuclease 1, isoform CRA_b
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000077 [DNA damage checkpoint]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0036297 [interstrand cross-link repair]
GO:0070530 [K63-linked polyubiquitin binding]
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 791 aa
85.8 kDa 		No 0
ATRIP-002
ENSP00000302338
ENST00000346691
Q8WXE1 [Direct mapping]
ATR-interacting protein
A0A024R307 [Target identity:100%; Query identity:100%]
Three prime repair exonuclease 1, isoform CRA_d
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0036297 [interstrand cross-link repair]
GO:0070530 [K63-linked polyubiquitin binding]
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 764 aa
83 kDa 		No 0
ATRIP-005
ENSP00000400930
ENST00000412052
Q8WXE1 [Direct mapping]
ATR-interacting protein
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0036297 [interstrand cross-link repair]
GO:0070530 [K63-linked polyubiquitin binding]
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 698 aa
76.3 kDa 		No 0
ATRIP-007
ENSP00000489608
ENST00000635099
C9IZM8 [Target identity:100%; Query identity:100%]
ATR-interacting protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
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 196 aa
22.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.