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APEH

GENERAL INFORMATION

Gene name

 APEH

Gene description

 Acylaminoacyl-peptide hydrolase

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most epithelia.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 4 antibodies.
HPA029700 , HPA029701 , HPA029702 , HPA029703
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY
HPA029700
HPA029701
HPA029702
HPA029703

GENE INFORMATION

Gene name

 APEH (HGNC Symbol)

Synonyms

 D3F15S2, D3S48E, DNF15S2

Description

 Acylaminoacyl-peptide hydrolase (HGNC Symbol)

Entrez gene summary

 This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 49674002 - 49683963

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164062 (version 83.38)

Entrez gene

 327

UniProt

 P13798 (UniProt - Evidence at protein level)

neXtProt

 NX_P13798

Antibodypedia

 APEH antibodies

PROTEIN BROWSER
APEH-001
APEH-002
APEH-003
APEH-012
APEH-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APEH-001
ENSP00000296456
ENST00000296456
P13798 [Direct mapping]
Acylamino-acid-releasing enzyme
A0A024R2U9 [Target identity:100%; Query identity:100%]
N-acylaminoacyl-peptide hydrolase, isoform CRA_b
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006415 [translational termination]
GO:0006508 [proteolysis]
GO:0008236 [serine-type peptidase activity]
GO:0008242 [omega peptidase activity]
GO:0010467 [gene expression]
GO:0031965 [nuclear membrane]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0050435 [beta-amyloid metabolic process]
GO:0070062 [extracellular exosome]
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 732 aa
81.2 kDa 		No 0
APEH-002
ENSP00000415862
ENST00000438011
C9JIF9 [Direct mapping]
Acylamino-acid-releasing enzyme
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   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0008236 [serine-type peptidase activity]
GO:0031965 [nuclear membrane]
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 737 aa
81.7 kDa 		No 0
APEH-003
ENSP00000414369
ENST00000449966
C9JLK2 [Direct mapping]
Acylamino-acid-releasing enzyme
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 232 aa
26 kDa 		No 0
APEH-012
ENSP00000410366
ENST00000457042
H7C393 [Direct mapping]
Acylamino-acid-releasing enzyme
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
GO:0031965 [nuclear membrane]
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 284 aa
31.9 kDa 		No 0
APEH-014
ENSP00000402365
ENST00000442186
H7C1U0 [Direct mapping]
Acylamino-acid-releasing enzyme
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 308 aa
34.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.