Tissue expression of GRM2 - Summary - The Human Protein Atlas

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GRM2

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	GRM2
Gene description	Glutamate receptor, metabotropic 2
Protein class	G-protein coupled receptors Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Tissue enhanced (cerebral cortex, testis)
FANTOM5:	Tissue enhanced (brain, cerebellum, hippocampus)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in CNS.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA065166
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex, testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (brain, cerebellum, hippocampus)

GENE INFORMATION
Gene name	GRM2 (HGNC Symbol)
Synonyms	GPRC1B, mGlu2, MGLUR2
Description	Glutamate receptor, metabotropic 2 (HGNC Symbol)
Entrez gene summary	L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p21.2
Chromosome location (bp)	51707070 - 51718613
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164082 (version 83.38)
Entrez gene	2912
UniProt	Q14416 (UniProt - Evidence at protein level)
neXtProt	NX_Q14416
Antibodypedia	GRM2 antibodies

PROTEIN BROWSER

GRM2-001	GRM2-005	GRM2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRM2-001 ENSP00000378492 ENST00000395052	Q14416 [Direct mapping] Metabotropic glutamate receptor 2 Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0001641 [group II metabotropic glutamate receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005246 [calcium channel regulator activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008066 [glutamate receptor activity] GO:0014047 [glutamate secretion] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030425 [dendrite] GO:0042734 [presynaptic membrane] GO:0043005 [neuron projection] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	872 aa 95.6 kDa	Yes	7
GRM2-005 ENSP00000408906 ENST00000442933	C9JL63 [Direct mapping] Metabotropic glutamate receptor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0001641 [group II metabotropic glutamate receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005246 [calcium channel regulator activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0042734 [presynaptic membrane] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	594 aa 65.5 kDa	Yes	2
GRM2-007 ENSP00000404797 ENST00000419928	C9JD41 [Direct mapping] Metabotropic glutamate receptor 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0001641 [group II metabotropic glutamate receptor activity] GO:0005246 [calcium channel regulator activity] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0042734 [presynaptic membrane] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	70 aa 7.3 kDa	Yes	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.