Expression of PPM1M in cancer - Summary - The Human Protein Atlas

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PPM1M

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PPM1M
Gene description	Protein phosphatase, Mg2+/Mn2+ dependent, 1M
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues and in a subset of immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining in cells/structures not annotated, view images. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA036905
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), lung cancer (favourable) and cervical cancer (favourable).
Renal cancer p<0.001 Lung cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036905

GENE INFORMATION
Gene name	PPM1M (HGNC Symbol)
Synonyms	FLJ32332, PP2Ceta
Description	Protein phosphatase, Mg2+/Mn2+ dependent, 1M (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p21.2
Chromosome location (bp)	52245793 - 52250597
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164088 (version 83.38)
Entrez gene	132160
UniProt	Q96MI6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96MI6
Antibodypedia	PPM1M antibodies

PROTEIN BROWSER

PPM1M-001	PPM1M-004	PPM1M-006	PPM1M-007	PPM1M-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPM1M-001 ENSP00000296487 ENST00000296487	Q96MI6 [Direct mapping] Protein phosphatase 1M Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Show all	GO:0003824 [catalytic activity] GO:0005634 [nucleus] GO:0006470 [protein dephosphorylation] GO:0008420 [CTD phosphatase activity] GO:0030145 [manganese ion binding] Show all	270 aa 30.4 kDa	No	0
PPM1M-004 ENSP00000387046 ENST00000409502	Q96MI6 [Direct mapping] Protein phosphatase 1M Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0003824 [catalytic activity] GO:0004721 [phosphoprotein phosphatase activity] GO:0005634 [nucleus] GO:0006470 [protein dephosphorylation] GO:0008420 [CTD phosphatase activity] GO:0030145 [manganese ion binding] Show all	247 aa 27.9 kDa	No	0
PPM1M-006 ENSP00000413556 ENST00000457454	H7C3S3 [Direct mapping] Protein phosphatase 1M Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0003824 [catalytic activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0006470 [protein dephosphorylation] Show all	257 aa 28.7 kDa	No	0
PPM1M-007 ENSP00000412344 ENST00000443681	H7C3K4 [Direct mapping] Protein phosphatase 1M Show all	Predicted intracellular proteins Show all	GO:0003824 [catalytic activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0006470 [protein dephosphorylation] Show all	121 aa 13.1 kDa	No	0
PPM1M-201 ENSP00000319894 ENST00000323588	B7XGB9 [Direct mapping] Protein phosphatase 1M; Protein phosphatase 2C eta-2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0006470 [protein dephosphorylation] Show all	459 aa 51.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.